芳香化酶P450在雌激素依赖性疾病病变内膜中的表达

被引：1

作者：

邹雪梅 ^{[1
]}

邓晓惠 ^{[2
]}

吴凯 ^{[3
]}

机构：

[1] 山东中医药大学第二附属医院妇产科

[2] 山东大学齐鲁医院妇产科

[3] 山东中医药大学附属医院病理科

来源：

中国妇产科临床杂志 | 2007年 / 01期

关键词：

芳香化酶P450; 子宫内膜; 免疫组化;

D O I：

10.13390/j.issn.1672-1861.2007.01.007

中图分类号：

R711.7 [女性生殖器其他疾病];

学科分类号：

100211 ;

摘要：

目的探讨芳香化酶P450(P450arom)在子宫内膜增生症、子宫腺肌病等雌激素依赖性疾病病变内膜中的不同表达。方法采用免疫组化方法分别测定子宫腺肌病异位内膜(Ⅰ组)、子宫腺肌病在位内膜(Ⅱ组)、子宫内膜增生症内膜(Ⅲ组)、正常子宫内膜(Ⅳ组)四组不同内膜中P450arom的表达。根据阳性率和表达强度进行量化评分(免疫组化评分)。结果①P450arom在子宫腺肌病异位、在位、子宫内膜增生症内膜中均阳性表达,但在正常子宫内膜无表达,P450arom在异位子宫内膜表达强度明显高于在位子宫内膜、增生症子宫内膜(P<0.05);异位子宫内膜病灶周围肌肉组织中也有P450arom表达;②P450arom在子宫内膜异位症内膜的增殖期和分泌期表达,差异无统计学意义(P>0.05)。结论①雌激素限速酶P450arom是子宫腺肌病、子宫内膜增生症等雌激素依赖性疾病发生、发展的重要激素,局部分子水平代谢紊乱可能导致疾病发生。②内膜P450arom检查不能作为盆腔子宫内膜异位症诊断方法,但可作为雌激素依赖性疾病筛选方法。

引用

页码：23 / 25+64+81 +64

页数：5

共 9 条

[1]

Aromatase and endometrio-sis. Bulun SE,Fang Z,I mir G,et al. Seminars in Reproductive Medicine . 2004

[2]

Aromataseinhibitor anastrozole for treating endometrial hyperplasia in obese. Agorastos T,Vaitsi V,Pantazis K,et al. European Journal of Obstetrics Gynecology and Reproductive Biology . 2005

[3]

Detection of aro-matase P450in endometrial biopsy speci mens as a diagnositic test for endometriosis. Kitawaki J,,Kusuki I,Koshiba H,et al. Fertility and Sterility . 1999

[4]

Prostaglandin E2sti mulates aromatase expressionin endometrosis-derived stroma1cells. Noble LS,Takayama K,Put man J M,et al. The Journal of Clinical Endocrinology . 1997

[5]

The effect of etonogestrel on VEGF oestrogen and progesterone receptor i m-munoreactivity and endothelial cell number in human edometri-um. Macpherson AM,Archer DF,Leslie S,et al. Human Reproduction . 1999

[6]

Data from the Ari midex,tamoxifen,alone or in combination(ATAC)trial:i mplications for use of aromatase in-hibitors in2003. Buzdar AU. Clinical Cancer Research . 2004

[7]

I mplication of decidual-ization associated protease expression in i mplantation and men-struation. Schatz F,Krikun G,Runic R,et al. Seminars in Reproductive Endocrinology . 1999

[8]

Multiple iso-forms of porcine aromatase are encoded by three distinct genes. Graddy I H,Kowalski AA,Sti mmen FA,et al. Journal of Steroid Biochemistry . 2000

[9]

Sti mulation of aromatase P450promoter(II)activity in endometriosis and its Inhibitionin endometrium are regulated by competive biding of steroidogenic factor-1and chicken ovalbumin upstreampromoter transcriptionfactor tothe same cis-acting element. Zeitoun K,Takayama K,Michael MD,et al. Mol.Endocri-nol . l999

← 1 →