X-连锁凋亡抑制蛋白在鼻咽癌中的表达及其意义

被引:5
作者
夏春波
蒋常文
周思
刘源劼
兰羚元
张幸
机构
[1] 桂林医学院人体解剖学教研室
关键词
鼻咽癌; XIAP基因; 凋亡抑制基因;
D O I
暂无
中图分类号
R739.63 [咽肿瘤];
学科分类号
100213 [耳鼻咽喉科学];
摘要
目的探讨X-连锁凋亡抑制蛋白(XIAP)表达在鼻咽癌发生发展过程中的作用,以及XIAP表达与鼻咽癌分化程度和淋巴转移的关系。方法应用RT-PCR法检测45例鼻咽癌组织、17例正常鼻咽组织和鼻咽癌细胞株5-8F、CNE-2中XIAP mRNA的表达,并通过免疫组化SP法检测鼻咽癌组织及癌旁组织XIAP蛋白的表达情况。结果 XIAP mRNA在5-8F、CNE-2和鼻咽癌组织中呈高表达,正常鼻咽组织不表达或低表达;鼻咽癌组织和正常鼻咽组织XIAP mRNA阳性检出率分别为86.67%(39/45)和35.29%(6/17)(P<0.01);在鼻咽癌组织和癌旁组织中,XIAP蛋白阳性检出率分别为82.22%(37/45)和24.44%(11/45)(P<0.01);鼻咽癌组织XIAP蛋白表达与肿瘤分级和淋巴转移无关(P>0.05)。结论 XIAP在鼻咽癌中高表达,可能在鼻咽癌发生过程中具有重要的作用。
引用
收藏
页码:2646 / 2649
页数:4
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