染料木黄酮植物性雌性激素治疗骨质疏松研究进展

被引：8

作者：

林忠

孙渊

杜有功

杨建苗

林建群

机构：

[1] 浙江省台州医院临床药学实验中心

来源：

中国临床药理学与治疗学 | 2014年 / 19卷 / 01期

关键词：

染料木黄酮; 植物性雌性激素; 抗骨质疏松;

D O I：

暂无

中图分类号：

R580 [];

学科分类号：

摘要：

本综述通过检索Google Scholar以及Science Direct查阅大量近10年的相关文献,对染料木黄酮抗骨质疏松机制、抗骨质疏松药效、药代动力学以及安全性多角度综述分析。结果表明染料木黄酮具有类似雌性激素作用,与雌性激素受体α的结合力大于雌性激素受体β的结合力,且发挥抗骨质疏松作用的主要作用受体是雌性激素受体α,在抗骨质疏松研究中无论是体内还是体外都具有较强的药理作用;其药理活性作用机制包括抑制骨髓巨噬细胞向破骨细胞转化的能力,抑制破骨细胞的增殖生长能力,诱导破骨细胞的凋亡,同时促进成骨细胞的增殖生长能力。骨质疏松的治疗效果确切,而毒副作用则明显的低于双磷酸盐和特立帕肽。植物雌性激素染料木黄酮可能在未来骨质疏松治疗过程中具有成为一线治疗药物的潜质

引用

页码：105 / 111

页数：7

共 20 条

[1]

Structural and histomorphometric evaluations of ferutinin effects on the uterus of ovariectomized rats during osteoporosis treatment.[J].Marzia Ferretti;Laura Bertoni;Francesco Cavani;Marta Benincasa;Paola Sena;Gianluca Carnevale;Manuela Zavatti;Vittoria Di Viesti;Paola Zanoli;Carla Palumbo.Life Sciences.2011, 3

[2]

Formononetin Prevents Ovariectomy-Induced Bone Loss in Rats [J].

Ha, Hyekyung ;

Lee, Ho Young ;

Lee, Je-Hyun ;

Jung, Dayoung ;

Choi, Jiyoon ;

Song, Kye-Yong ;

Jung, Hee Jin ;

Choi, Jae Sue ;

Chang, Soo-Ik ;

Kim, Chungsook .

ARCHIVES OF PHARMACAL RESEARCH, 2010, 33 (04) :625-632

[3]

Breast Safety and Efficacy of Genistein Aglycone for Postmenopausal Bone Loss: A Follow-Up Study [J].

Marini, Herbert ;

Bitto, Alessandra ;

Altavilla, Domenica ;

Burnett, Bruce P. ;

Polito, Francesca ;

Di Stefano, Vincenzo ;

Minutoli, Letteria ;

Atteritano, Marco ;

Levy, Robert M. ;

D'Anna, Rosario ;

Frisina, Nicola ;

Mazzaferro, Susanna ;

Cancellieri, Francesco ;

Cannata, Maria Letizia ;

Corrado, Francesco ;

Frisina, Alessia ;

Adamo, Vincenzo ;

Lubrano, Carla ;

Sansotta, Carlo ;

Marini, Rolando ;

Adamo, Elena Bianca ;

Squadrito, Francesco .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2008, 93 (12) :4787-4796

[4]

Effects of soy isoflavone consumption on bone structure and milk mineral concentration in a rat model of lactation-associated bone loss [J].

Peterson, Catherine A. ;

Schnell, Jennifer D. ;

Kubas, Karen L. ;

Rottinghaus, George E. .

EUROPEAN JOURNAL OF NUTRITION, 2009, 48 (02) :84-91

[5]

Osteogenic activities of genistein derivatives were influenced by the presence of prenyl group at ring a [J].

Zhang, Yan ;

Li, Xiao-Li ;

Yao, Xin-Sheng ;

Wong, Man-Sau .

ARCHIVES OF PHARMACAL RESEARCH, 2008, 31 (12) :1534-1539

[6]

Estrogenic activities of isoflavones and flavones and their structure-activity relationships [J].

Choi, Sun Young ;

Ha, Tae Youl ;

Ahn, Ji Yun ;

Kim, Sung Ran ;

Kang, Kyung Sun ;

Hwang, In Kyeong ;

Kim, Suna .

PLANTA MEDICA, 2008, 74 (01) :25-32

[7]

Effects of genistein on vertebral trabecular bone microstructure, bone mineral density, microcracks, osteocyte density, and bone strength in ovariectomized rats [J].

Dai, Ruchun ;

Ma, Yulin ;

Sheng, Zhifeng ;

Jin, Yan ;

Zhang, Yuhai ;

Fang, Lingna ;

Fan, Huijie ;

Liao, Eryuan .

JOURNAL OF BONE AND MINERAL METABOLISM, 2008, 26 (04) :342-349

[8]

The bone-protective effect of the phytoestrogen genistein is mediated via ERα-dependent mechanisms and strongly enhanced by physical activity [J].

Hertrampf, T. ;

Gruca, M. J. ;

Seibel, J. ;

Laudenbach, U. ;

Fritzemeier, K. H. ;

Diel, P. .

BONE, 2007, 40 (06) :1529-1535

[9]

Genistein and zinc synergistically stimulate apoptotic cell death and suppress RANKL signaling-related gene expression in osteoclastic cells [J].

Uchiyama, Satoshi ;

Yamaguchi, Masayoshi .

JOURNAL OF CELLULAR BIOCHEMISTRY, 2007, 101 (03) :529-542

[10]

Glucocorticoid-Induced Osteoporosis: Mechanisms and Therapeutic Approach.[J].Jean-Pierre Devogelaer.Rheumatic Disease Clinics of North America.2006, 4

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