调血脂新药阿伐他汀的药理作用与临床应用

被引:11
作者
邢旺兴
机构
[1] 第二军医大学药学院!上海
关键词
阿伐他汀; HMG-CoA还原酶抑制剂; 高胆固醇血症; 动脉粥样硬化;
D O I
10.13220/j.cnki.jipr.1998.06.006
中图分类号
R972 [心血管系统药物];
学科分类号
1007 ;
摘要
阿伐他汀 (atorvastatin)是一种全合成的 HMG- Co A还原酶抑制剂 ,临床前及临床研究显示 ,该药能通过抑制内源性胆固醇的合成 ,明显降低血清胆固醇和甘油三酯水平 ,尚有抗动脉粥样硬化的作用 ;对原发性高胆固醇血症、高甘油三酯血症、家族性高胆固醇血症和混合性高脂血症等各种类型的血脂异常均有效。本文对阿伐他汀的药理作用、药代动力学、药物相互作用、临床应用和不良反应等作一概述
引用
收藏
页码:341 / 345
页数:5
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