黄嘌呤-黄嘌呤氧化酶对培养心肌细胞的损伤及硒的保护作用

被引：1

作者：

王雪青

江岩

董力

机构：

[1] 河北医科院病生室,河北医科院病生室,河北医科院病生室

来源：

中国病理生理杂志 | 1991年 / 03期

关键词：

细胞; 培养的; 游离基类; 硒; 动作电位; 膜;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

向培养心肌细胞中加入黄嘌呤-黄嘌呤氧化酶（X-XOD）后,动作电位的APA、OS、Vmax及APD减少,MDP、TP水平上移;细胞在MEM中搏动率降低,加钡后细胞收缩频率迅速增加,且X-XOD作用时间越长,上述改变越显著。X-Mo的作用与此类似,但较轻。加硒则能逆转上述的细胞损伤性变化。这表明X-XOD和X-Mo均能造成心肌细胞损伤,硒对心肌细胞有保护作用。

引用

页码：281 / 285

页数：5

共 6 条

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