缺血性脑水肿的病理生理研究进展

被引：32

作者：

任丽

机构：

[1] 重庆医科大学神经生物学研究室

来源：

国外医学神经病学神经外科学分册. | 2003年 / 05期

关键词：

缺血性脑水肿; 水通道蛋白; 血脑屏障; 炎性反应; 自由基;

D O I：

10.16636/j.cnki.jinn.2003.05.008

中图分类号：

R743.3 [急性脑血管疾病（中风）];

学科分类号：

摘要：

脑水肿是缺血性脑血管病的常见并发症,它的产生是一个复杂的病理生理过程。目前研究表明缺血性脑水肿与水通道蛋白(aquaporins,AQPs)表达的变化、血脑屏障通透性的增加、脑缺血后出现的炎性反应及可引起多种损伤的自由基的作用等多种因素有关。其中,AQPs是新近发现的一组具有水选择性的细胞膜转运蛋白,特别是AQP4和AQP5与缺血性脑水肿有着较为密切的关系。

引用

页码：423 / 427

页数：5

共 12 条

[1]

The cytosolic antioxidant, copper/zinc superoxide dismutase, attenuates blood–brain barrier disruption and oxidative cellular injury after photothrombotic cortical ischemia in mice[J] . G.W Kim,A Lewén,J.-C Copin,B.D Watson,P.H Chan.Neuroscience . 2001 (4)

[2] Alterations in the expression of the AQP family in cultured rat astrocytes during hypoxia and reoxygenation [J].

Yamamoto, N ;

Yoneda, K ;

Asai, K ;

Sobue, K ;

Tada, T ;

Fujita, Y ;

Katsuya, H ;

Fujita, M ;

Aihara, N ;

Mase, M ;

Yamada, K ;

Miura, Y ;

Kato, T .

MOLECULAR BRAIN RESEARCH, 2001, 90 (01) :26-38

[3]

Induction of aquaporin-4 water channel mRNA after focal cerebral ischemia in rat[J] . Masaaki Taniguchi,Toshihide Yamashita,Eiji Kumura,Michio Tamatani,Akihiro Kobayashi,Takashi Yokawa,Motohiko Maruno,Amami Kato,Takanori Ohnishi,Eiji Kohmura,Masaya Tohyama,Toshiki Yoshimine.Molecular Brain Research . 2000 (1)

[4]

Early Appearance of Activated Matrix Metalloproteinase-9 after Focal Cerebral Ischemia in Mice: A Possible Role in Blood—Brain Barrier Dysfunction[J] . Yvan Gasche,Miki Fujimura,Yuiko Morita-Fujimura,Jean-Christophe Copin,Makoto Kawase,Justin Massengale,Pak H. Chan.Journal of Cerebral Blood Flow & Metabolism . 1999 (9)

[5]

Differential Upregulation of Aquaporin-4 mRNA Expression in Reactive Astrocytes after Brain Injury: Potential Role in Brain Edema[J] . Neurobiology of Disease . 1999 (4)

[6]

Early appearance of activated matrix metalloproteinase-9 and blood–brain barrier disruption in mice after focal cerebral ischemia and reperfusion[J] . Miki Fujimura,Yvan Gasche,Yuiko Morita-Fujimura,Justin Massengale,Makoto Kawase,Pak H Chan.Brain Research . 1999 (1)

[7] Matrix metalloproteinases increase very early during experimental focal cerebral ischemia [J].

Heo, JH ;

Lucero, J ;

Abumiya, T ;

Koziol, JA ;

Copeland, BR ;

del Zoppo, GJ .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1999, 19 (06) :624-633

[8] Nitric oxide synthase immunoreactivity related to cold-induced brain edema [J].

Gotoh, K ;

Kikuchi, H ;

Kataoka, H ;

Nagata, I ;

Nozaki, K ;

Takahashi, JC ;

Hazama, F .

NEUROLOGICAL RESEARCH, 1998, 20 (07) :637-642

[9]

Cellular localization of tumor necrosis factor alpha following focal cerebral ischemia in mice[J] . Chao Gong,Zhen Qin,A.Lorris Betz,Xiao-Hong Liu,Guo-Yuan Yang.Brain Research . 1998 (1)

[10]

Quantitative evaluation of blood-brain barrier permeability following middle cerebral artery occlusion in rats[J] . Ludmila Belayev,Raul Busto,Weizhao Zhao,Myron D Ginsberg.Brain Research . 1996 (1)

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