原发性胆汁性肝硬化的研究进展

被引:23
作者
贾继东
段维佳
机构
[1] 首都医科大学附属北京友谊医院肝病中心
关键词
肝硬化,胆汁性; 诊断; 治疗; 机制;
D O I
暂无
中图分类号
R575.2 [肝硬变];
学科分类号
100201 [内科学];
摘要
<正>原发性胆汁性肝硬化(primary biliary cirrhosis,PBC)是以肝内小胆管进行性、非化脓性、破坏性炎症为特征的慢性胆汁淤积性疾病,可发展至肝纤维化及肝硬化。近年来,关于PBC的发病机制、诊断及治疗有较多的报道,也取得了一定的进展。一、发病机制PBC的发病机制尚未完全阐明,但目前认为可
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共 8 条
[1]
Biliary Apotopes and Anti-Mitochondrial Antibodies Activate Innate Immune Responses in Primary Biliary Cirrhosis [J].
Lleo, Ana ;
Bowlus, Christopher L. ;
Yang, Guo-Xiang ;
Invernizzi, Pietro ;
Podda, Mauro ;
Van de Water, Judy ;
Ansari, Aftab A. ;
Coppel, Ross L. ;
Worman, Howard J. ;
Gores, Gregory J. ;
Gershwin, M. Eric .
HEPATOLOGY, 2010, 52 (03) :987-998
[2]
PBC Screen An IgG/IgA dual isotype ELISA detecting multiple mitochondrial and nuclear autoantibodies specific for primary biliary cirrhosis [J].
Liu, Haiying ;
Norman, Gary L. ;
Shums, Zakera ;
Worman, Howard J. ;
Krawitt, Edward L. ;
Bizzaro, Nicola ;
Vergani, Diego ;
Bogdanos, Dimitrios P. ;
Dalekos, George N. ;
Milkiewicz, Piotr ;
Czaja, Albert J. ;
Heathcote, E. Jenny ;
Hirschfield, Gideon M. ;
Tan, Eng M. ;
Miyachi, Kiyomitsu ;
Bignotto, Monica ;
Battezzati, Pier Maria ;
Lleo, Ana ;
Leung, Patrick S. ;
Podda, Mauro ;
Gershwin, M. Eric ;
Invernizzi, Pietro .
JOURNAL OF AUTOIMMUNITY, 2010, 35 (04) :436-442
[3]
Deletion of Interleukin-12p40 Suppresses Autoimmune Cholangitis in Dominant Negative Transforming Growth Factor β Receptor Type II Mice [J].
Yoshida, Katsunori ;
Yang, Guo-Xiang ;
Zhang, Weici ;
Tsuda, Masanobu ;
Tsuneyama, Koichi ;
Moritoki, Yuki ;
Ansari, Aftab A. ;
Okazaki, Kazuichi ;
Lian, Zhe-Xiong ;
Coppel, Ross L. ;
Mackay, Ian R. ;
Gershwin, M. Eric .
HEPATOLOGY, 2009, 50 (05) :1494-1500
[4]
Treatment with Immunosuppressives in Patients with Primary Biliary Cirrhosis Who Fail to Respond to Ursodiol [J].
Kaplan, Marshall M. ;
Poupon, Raoul .
HEPATOLOGY, 2009, 50 (02) :652-652
[5]
EASL Clinical Practice Guidelines: Management of cholestatic liver diseases [J].
Beuers, Ulrich ;
Boberg, Kirsten M. ;
Chapman, Roger W. ;
Chazouilleres, Olivier ;
Invernizzi, Pietro ;
Jones, David E. J. ;
Lammert, Frank ;
Pares, Albert ;
Trauner, Michael .
JOURNAL OF HEPATOLOGY, 2009, 51 (02) :237-267
[6]
New ELISA for Detecting Primary Biliary Cirrhosis-Specific Antimitochondrial Antibodies [J].
Daehnrich, Cornelia ;
Pares, Albert ;
Caballeria, Llorenc ;
Rosemann, Anke ;
Schlumberger, Wolfgang ;
Probst, Christian ;
Mytilinaiou, Maria ;
Bogdanos, Dimitrios ;
Vergani, Diego ;
Stoecker, Winfried ;
Komorowski, Lars .
CLINICAL CHEMISTRY, 2009, 55 (05) :978-985
[7]
Apotopes and the Biliary Specificity of Primary Biliary Cirrhosis [J].
Lleo, Ana ;
Selmi, Carlo ;
Invernizzi, Pietro ;
Podda, Mauro ;
Coppel, Ross L. ;
Maclay, Ian R. ;
Gores, Gregory J. ;
Ansari, Aftab A. ;
de Water, Judy Van ;
Gershwin, M. Eric .
HEPATOLOGY, 2009, 49 (03) :871-879
[8]
Excellent long-term survival in patients with primary biliary cirrhosis and biochemical response to ursodeoxycholic acid [J].
Parés, A ;
Caballería, L ;
Rodés, J .
GASTROENTEROLOGY, 2006, 130 (03) :715-720