严重脓毒症心肌损伤患者血浆Apelin水平与cTnI相关性研究

被引：8

作者：

童静 ^{[1
]}

张明 ^{[2
]}

陈如杰 ^{[2
]}

范小芳 ^{[3
]}

机构：

[1] 浙江省温州医科大学附属第二医院急救中心

[2] 浙江省温州医科大学附属第二医院重症医学科

[3] 浙江省温州医科大学附属第二医院机能实验教学中心

来源：

中华全科医学 | 2014年 / 12卷 / 05期

关键词：

脓毒症; 严重脓毒症; 脓毒性休克; 心肌损伤; Apelin; cTnI; NT-pro BNP; APACHEⅡ;

D O I：

10.16766/j.cnki.issn.1674-4152.2014.05.008

中图分类号：

R459.7 [急症、急救处理];

学科分类号：

100231 [临床病理学];

摘要：

目的观察脓毒症心肌损伤患者血浆Apelin水平并探讨其与cTnI关系。方法入选79例脓毒症患者经肘静脉途径采血,测定血浆Apelin、cTnI、NT-pro BNP等指标;同期17例健康志愿者为对照(NC组)。结果①血浆Apelin水平,与NC组比较,A组有升高趋势(P>0.05)、B及C组有明显升高(P<0.01);与A组比较,B组有升高(P<0.05),C组升高(P<0.01);②血浆cTnI水平,与A组比较,B组有升高(P<0.05),C组升高(P<0.01);与B组比较,C组升高(P<0.05);③血浆NT-pro BNP水平,与NC组比较,A组差异无统计学意义(P>0.05),B、C组有升高(P<0.01);与B组比较,C组升高(P<0.05);④入院时APACHEⅡ评分,与NC组比较,A组差异无统计学意义(P>0.05),B、C两组差异有统计学意义(P<0.01);与B组比较,C组有升高但差异无统计学意义(P>0.05);⑤脓毒症相关心肌损伤患者血浆Apelin水平与cTnI水平有相关性(r=0.482,P<0.05),与NT-Pro BNP有正相关(r=0.517,P<0.05),与入院时APACHEⅡ得分有正相关(r=0.429,P<0.05)。结论脓毒症患者血浆Apelin水平升高,脓毒症相关心肌损伤患者血浆Apelin水平随病情加重而明显升高,与cTnI、NTPro BNP水平及APACHEⅡ相关,提示血浆Apelin参与脓毒症心肌损伤的病理生理过程,有一定的临床意义。

引用

页码：691 / 693+752 +752

页数：4

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