HGF/c-Met信号通路与胃癌相关研究进展

被引：4

作者：

赖莹莹

吴小翎

机构：

[1] 重庆医科大学附属第二医院消化内科

来源：

保健医学研究与实践 | 2013年 / 10卷 / 04期

关键词：

HGF; c-Met; 信号通路; 胃癌;

D O I：

暂无

中图分类号：

R735.2 [胃肿瘤];

学科分类号：

100112 [医学生物化学与分子生物学];

摘要：

胃癌是世界上最常见的恶性肿瘤之一,主要治疗方式为手术、化疗和放疗,但是临床效果却不尽如人意。目前针对胃癌靶向治疗仍不理想,单一的靶向治疗易导致耐药及肿瘤复发,多靶点联合用药将是胃癌分子靶向治疗的一个发展趋势。本文介绍了肝细胞生长因子(HGF)/肝细胞生长因子受体(c-Met)信号转导通路参与胃癌的发生、发展和侵袭转移,是极具潜力的胃癌治疗靶点。目前研究中涌现出大量靶向该通路的药物并在临床研究中取得成果,但由于种族及胃癌亚型不同,仍然面临许多挑战。更深入的研究HGF/c-Met信号转导通路的作用机制,多渠道筛选独特分子亚型的胃癌患者用以进行针对性的靶向临床试验等可为胃癌治疗提供新的思路。

引用

页码：74 / 77+83 +83

页数：5

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