机械敏感性离子通道蛋白Piezo在机体机械转导中作用的研究进展

被引：4

作者：

高瑞桐

许林琪

李峰

机构：

[1] 吉林大学护理学院内科教研室

来源：

吉林大学学报(医学版) | 2019年 / 45卷 / 03期

关键词：

机械敏感性离子通道; Piezo1; Piezo2; 机械转导;

D O I：

10.13481/j.1671-587x.20190345

中图分类号：

R346 [];

学科分类号：

摘要：

Piezo1和Piezo2是近年来新发现的机械敏感性离子通道,对机械门控非选择性阳离子电流的产生至关重要,在机械转导过程中发挥重要作用。本文系统地总结了国内外相关文献,重点论述Piezo通道在组织器官中的分布及表达,阐述其在机械转导途径中的作用,探讨其在不同组织器官中的表达及对机械转导作用的影响,为揭示Piezo基因相关的人类疾病探索新的路径。本文就Piezo家族对生物体生理功能的重要性及其与疾病的相关性进行介绍,主要概述Piezo通道的发现过程,总结Piezo1通道在血管、膀胱和肾脏等组织器官中的机械转导功能及Piezo2通道在触觉、本体感觉和伤害感觉等感觉系统中的机械转导功能,并介绍Piezo1和Piezo2突变体与多种人类疾病的关联,展望其作为重要基因或药物治疗靶点的前景。

引用

页码：725 / 730

页数：6

共 15 条

[1]

Mechanosensitive ion channel Piezo2 is important for enterochromaffin cell response to mechanical forces [J].

Wang, Fan ;

Knutson, Kaitlyn ;

Alcaino, Constanza ;

Linden, David R. ;

Gibbons, Simon J. ;

Kashyap, Purna ;

Grover, Madhusudan ;

Oeckler, Richard ;

Gottlieb, Philip A. ;

Li, Hui Joyce ;

Leiter, Andrew B. ;

Farrugia, Gianrico ;

Beyder, Arthur .

JOURNAL OF PHYSIOLOGY-LONDON, 2017, 595 (01) :79-91

[2]

The potential role of Piezo2 in the mediation of visceral sensation.[J].Jing Yang;Jianna Zhang;Hongli Yang;Kun Li;Xiaofei Lei;Changqing Xu.Neuroscience Letters.2016,

[3]

Piezo1 expression increases in rat bladder after partial bladder outlet obstruction.[J].Mai Michishita;Kazuo Yano;Ken-ichi Tomita;Osamu Matsuzaki;Ken-ichi Kasahara.Life Sciences.2016,

[4]

Contribution of Piezo2 to Endothelium-Dependent Pain.[J].Luiz F. Ferrari;Oliver Bogen;Paul Green;Jon D. Levine.Molecular Pain.2015, 1

[5]

Mechanically Activated Ion Channels [J].

Ranade, Sanjeev S. ;

Syeda, Ruhma ;

Patapoutian, Ardem .

NEURON, 2015, 87 (06) :1162-1179

[6]

Piezo1 in Smooth Muscle Cells Is Involved in Hypertension-Dependent Arterial Remodeling [J].

Retailleau, Kevin ;

Duprat, Fabrice ;

Arhatte, Malika ;

Ranade, Sanjeev Sumant ;

Peyronnet, Remi ;

Martins, Joana Raquel ;

Jodar, Martine ;

Moro, Celine ;

Offermanns, Stefan ;

Feng, Yuanyi ;

Demolombe, Sophie ;

Patel, Amanda ;

Honore, Eric .

CELL REPORTS, 2015, 13 (06) :1161-1171

[7]

Three-dimensional Imaging Reveals New Compartments and Structural Adaptations in Odontoblasts [J].

Shahidi, M. Khatibi ;

Krivanek, J. ;

Kaukua, N. ;

Ernfors, P. ;

Hladik, L. ;

Kostal, V. ;

Masich, S. ;

Hampl, A. ;

Chubanov, V. ;

Gudermann, T. ;

Romanov, R. A. ;

Harkany, T. ;

Adameyko, I. ;

Fried, K. .

JOURNAL OF DENTAL RESEARCH, 2015, 94 (07) :945-954

[8]

Piezo channels: from structure to function.[J].Linda Volkers;Yasmine Mechioukhi;Bertrand Coste.Pflügers Archiv - European Journal of Physiology.2015, 1

[9]

Mutations in PIEZO2 Cause Gordon Syndrome, Marden-Walker Syndrome, and Distal Arthrogryposis Type 5 [J].

McMillin, Margaret J. ;

Beck, Anita E. ;

Chong, Jessica X. ;

Shively, Kathryn M. ;

Buckingham, Kati J. ;

Gildersleeve, Heidi I. S. ;

Aracena, Mariana I. ;

Aylsworth, Arthur S. ;

Bitoun, Pierre ;

Carey, John C. ;

Clericuzio, Carol L. ;

Crow, Yanick J. ;

Curry, Cynthia J. ;

Devriendt, Koenraad ;

Everman, David B. ;

Fryer, Alan ;

Gibson, Kate ;

Uzielli, Maria Luisa Giovannucci ;

Graham, John M., Jr. ;

Hall, Judith G. ;

Hecht, Jacqueline T. ;

Heidenreich, Randall A. ;

Hurst, Jane A. ;

Irani, Sarosh ;

Krapels, Ingrid P. C. ;

Leroy, Jules G. ;

Mowat, David ;

Plant, Gordon T. ;

Robertson, Stephen P. ;

Schorry, Elizabeth K. ;

Scott, Richard H. ;

Seaver, Laurie H. ;

Sherr, Elliott ;

Splitt, Miranda ;

Stewart, Helen ;

Stumpel, Constance ;

Temel, Sehime G. ;

Weaver, David D. ;

Whiteford, Margo ;

Williams, Marc S. ;

Tabor, Holly K. ;

Smith, Joshua D. ;

Shendure, Jay ;

Nickerson, Deborah A. ;

Washington, Univ ;

Bamshad, Michael J. .

AMERICAN JOURNAL OF HUMAN GENETICS, 2014, 94 (05) :734-744

[10]

The Structure of a Conserved Piezo Channel Domain Reveals a Topologically Distinct β Sandwich Fold [J].

Kamajaya, Aron ;

Kaiser, Jens T. ;

Lee, Jonas ;

Reid, Michelle ;

Rees, Douglas C. .

STRUCTURE, 2014, 22 (10) :1520-1527

← 1 2 →