欧前胡素抗抑郁作用及机制研究

被引：10

作者：

郑星星 ^{[1
,2
]}

刘嘉辉 ^{[1
]}

刘明辉 ^{[1
]}

程颖 ^{[1
]}

曹艳君 ^{[1
,2
]}

机构：

[1] 西北大学生命科学学院西部资源生物与生物技术教育部重点实验室

[2] 西北大学生命科学学院陕西省生物医药重点实验室

来源：

中国药理学通报 | 2019年 / 35卷 / 01期

关键词：

欧前胡素; 抑郁; 产前应激; 5-HT; 5-HTT; 5-HT1AR;

D O I：

暂无

中图分类号：

R285.5 [中药实验药理];

学科分类号：

100806 [中药药理学];

摘要：

目的探讨欧前胡素（IMP）的抗抑郁作用及其机制。方法采用产前束缚应激对孕后期♀鼠建立抑郁模型,将SD♂子代大鼠随机分为5组,每组8只。分别是正常组（CON）、模型组（PS）、阳性组(氟西汀5 mg·kg-1·d-1)、IMP低、高剂量组(15、30 mg·kg-1·d-1)。均采用灌胃给药,每天1次,连续给药4周。进行糖水偏好、强迫游泳、旷场实验行为学测试,ELISA法、实时定量PCR检测海马及前额叶皮层中5-HT的浓度、5-HTT和5-HT1AR的mRNA表达量。结果 IMP给药4周后,与PS组相比,IMP组糖水偏好度明显上升,不动时间减少,穿越总格子数、穿越中间格子数、直立和理毛次数明显增加（P<0.05,P<0.01）,5-HT的浓度及5-HT1AR的mRNA表达明显升高（P<0.05,P<0.01）,5-HTT mRNA的表达明显降低（P<0.05,P<0.01）。结论 IMP可明显改善PS♂子代抑郁样行为,具有抗抑郁作用,其机制可能与升高5-HT浓度及5-HT1A R mRNA的表达,降低5-HTT mRNA的表达有关。

引用

页码：101 / 105

页数：5

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