长春西汀微乳的优化及其理化性质的考察

被引：22

作者：

李华

潘卫三

吴振

李嘉煜

夏立新

机构：

[1] 沈阳药科大学药剂教研室

[2] 沈阳药科大学中药学院

[3] 中国医科大学第一临床学院

来源：

药学学报 | 2004年 / 09期

关键词：

长春西汀; 微乳; 经皮给药; 单纯形网格法; Hacat细胞;

D O I：

10.16438/j.0513-4870.2004.09.003

中图分类号：

R94 [药剂学];

学科分类号：

100602 ; 100702 ;

摘要：

目的选择适宜比例的油相、表面活性剂、助表面活性剂和水相制备长春西汀微乳制剂以增加药物的溶解度和经皮渗透量,优化处方,并对其理化性质和刺激性进行研究。方法绘制伪三元相图,确定各相的比例,以经皮稳态渗透流量为指标,利用单纯形网格法优化处方,并考察优化微乳的pH、粘度、电导率、折光率、粒径分布等理化性质。采用MTT法考察微乳制剂对人体皮肤细胞系模型Hacat细胞的毒性。结果 O/W微乳在相图中的区域随着表面活性剂和助表面活性剂比例的增加而增加;单纯形网格优化法预测的指标值与实测值相近,所得的优化微乳性质稳定,对Hacat细胞无刺激性,与阴性组无显著性差异。结论长春西汀微乳制剂中药物的溶解度极大提高,经皮稳态渗透流量显著增大,安全稳定,可作为经皮给药的新型载体。

引用

页码：681 / 685

页数：5

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