诱导性多能干细胞在治疗性血管新生方面的研究进展

被引：1

作者：

张雪

张岚

机构：

[1] 上海交通大学医学院附属仁济医院血管外科

来源：

中华普通外科杂志 | 2016年 / 31卷 / 11期

关键词：

D O I：

暂无

中图分类号：

R654.4 [周围血管];

学科分类号：

100408 [卫生政策与卫生管理学];

摘要：

<正>下肢动脉硬化闭塞症（arteriosclerosis obliterans,ASO）是老年人常见的血管疾病[1]。欧美国家70岁以上人群中的患病率为18.59%[2],我国60岁以上人群的患病率为16.42%3]。虽然血管腔内介入治疗及旁路手术也取得了一定的临床疗效,仍有近1/3的患者在治疗后数年出现血管再狭窄和闭塞,最终发展为重症下肢缺血（critical limb ischemia,CLI）,其中16%的患者被迫截肢[4]。近年来,干细胞与血管新生的关系及在治疗性血管新生中的作用备受关注。研究表明,诱导性多能干细胞(induced pluripotent stem

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