EGFR基因突变与肺腺癌新分类及临床病理特征的关系

被引：11

作者：

贺锐 ^{[1
]}

李建民 ^{[2
]}

王跃华 ^{[2
]}

高宁 ^{[2
]}

机构：

[1] 山西医科大学基础医学院

[2] 山西省肿瘤医院病理科

来源：

临床与实验病理学杂志 | 2013年 / 29卷 / 12期

关键词：

肺肿瘤; 腺癌; 新分类; 表皮生长因子受体; 基因突变;

D O I：

10.13315/j.cnki.cjcep.2013.12.028

中图分类号：

R734.2 [肺肿瘤];

学科分类号：

100214 ;

摘要：

目的根据2011年国际肺癌研究协会、美国胸科学会和欧洲呼吸学会发布的肺腺癌国际多学科分类(简称新分类)标准,评估新分类法与EGFR突变之间的相关性。方法收集2010～2012年肺腺癌标本共292例,其中145例手术标本分别使用新分类和WHO(2004版)分类(简称WHO分类)进行组织分型,并用基因直接测序法对所有标本EGFR基因外显子18～21(E18～21)进行检测。结果有123例(42.1%)标本发生EGFR突变,新分类法中各组织学亚型之间突变情况不同(P=0.006),EGFR突变多发于贴壁、微乳头为主的肺腺癌,含贴壁结构、乳头结构和微乳头结构亚型的肺腺癌,少见于腺泡、实体为主伴黏蛋白型(实体为主)及含浸润变异结构的肺腺癌。按WHO分类各亚型之间EGFR突变无明显差异。结论新分类表现出与分子诊断的相关性,其提倡的按5%增量的半定量方式将>5%的各组织学亚型及其所占百分比全面计入诊断(5%增量半定量法)的综合分类法应该被推广。

引用

页码：1323 / 1328

页数：6

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