3D-ASL技术在短暂性脑缺血发作中的应用研究

被引:25
作者
张丽娜 [1 ]
姜航 [1 ]
骆众星 [1 ]
龙柳 [1 ]
陈少琼 [1 ]
康庄 [1 ]
李征然 [2 ]
机构
[1] 广州, 中山大学附属第三医院放射科
[2] 广州, 中山大学附属第三医院介入血管科
关键词
动脉自旋标记技术; 脑灌注; 弥散加权成像; 磁共振血管成像; 短暂性脑缺血发作; 标记延迟时间;
D O I
暂无
中图分类号
R743.31 [短暂性脑缺血]; R445.2 [核磁共振成像];
学科分类号
100204 [神经病学]; 100231 [临床病理学];
摘要
目的评价3.0T磁共振三维动脉自旋标记技术(3D-ASL)在短暂性脑缺血发作(TIA)患者中的应用。方法选取中山大学附属第三医院神经内科自2014年7月至2017年3月收治的TIA患者42例, 均行常规MRI、弥散加权成像(DWI)、磁共振血管成像(MRA)及3D-ASL检查。分析患者常规MRI、DWI及MRA有无异常信号影及脑动脉狭窄、闭塞;对3D-ASL图像进行后处理得到全脑血流量(CBF)图, 定性、定量分析ASL-CBF图有无异常灌注;比较3D-ASL[标记延迟时间(PLD)=1.5 s、PLD=2.5 s]、MRA对TIA患者脑灌注减低的检出率。结果 42例TIA患者的常规MRI及DWI序列上均无阳性表现, MRA提示颅内动脉中重度狭窄患者18例(42.86%)。3D-ASL(PLD=1.5 s)显示脑灌注减低27例(64.29%), 3D-ASL(PLD=2.5 s)显示脑灌注减低21例(50%)。统计显示3D-ASL(PLD=1.5 s)对TIA患者脑灌注减低的检出率高于3D-ASL(PLD=2.5 s)检查, 差异有统计学意义(χ2=23.333, P=0.000);3D-ASL(PLD=1.5 s)及3D-ASL(PLD=2.5 s)对TIA患者脑灌注减低的检出率均高于MRA, 差异有统计学意义(χ2=17.500, P=0.000;χ2=31.500, P=0.000)。结论 3D-ASL有助于早期发现TIA患者局部脑组织灌注异常及程度。不同PLD对病灶的检出率及范围有差异, 较短PLD能提高检出率, 较长PLD能更真实反映血管狭窄较严重TIA患者的脑灌注情况, 更好地指导临床治疗。
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