糖皮质激素对固有免疫细胞作用机制的研究进展

被引：5

作者：

谢冠群

季巾君

徐莉

范永升

机构：

[1] 浙江中医药大学

来源：

浙江中医药大学学报 | 2013年 / 37卷 / 02期

关键词：

糖皮质激素; 固有免疫; 中性粒细胞; 巨噬细胞; 自然杀伤细胞; 树突状细胞;

D O I：

10.16466/j.issn1005-5509.2013.02.026

中图分类号：

R363 [病理生理学];

学科分类号：

100103 [病原生物学];

摘要：

[目的]综述糖皮质激素(glucocorticoid,GC)对固有免疫细胞作用机制的研究进展。[方法]以"glucocorticoid,innate immune,neutrophile granulo-cyte,macrophage,NK cell,dendritic cell"为关键词,在PubMed数据库中检索GC作用于固有免疫细胞的文献进行检索。[结果与结论]GC在调控固有免疫细胞中具有重要作用,虽然GC主要表现为抑制炎症及免疫功能,但在多种情况下,如GC不能诱导NEU凋亡、GC促进具有拮抗GC功能的MIF的表达等都表明GC具有多方面的功能。因此,进一步深入研究GC对固有免疫细胞的作用,对阐明GC的作用机制具有重要的意义。

引用

收藏

页码：213 / 216

页数：4

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