益赛普联合甲氨蝶呤片治疗老年类风湿关节炎患者的临床疗效

被引：17

作者：

秦卫红

廖香

卜一芝

周游

谭玉梅

机构：

[1] 北海市人民医院风湿免疫科

来源：

中国老年学杂志 | 2022年 / 42卷 / 05期

关键词：

益赛普; 甲氨蝶呤片; 类风湿关节炎(RA); 血清学;

D O I：

暂无

中图分类号：

R593.22 [类风湿性关节炎];

学科分类号：

100201 [内科学];

摘要：

目的分析重组人Ⅱ型肿瘤坏死因子受体-抗体融合蛋白(益赛普)联合甲氨蝶呤片治疗老年类风湿关节炎(RA)患者的临床疗效。方法选取80例老年RA患者，随机分为对照组、实验组，每组40例。对照组给予口服甲氨蝶呤片，实验组在对照组基础上应用益赛普治疗。比较两组治疗第12、24周后关节晨僵持续时间、双手握力、关节疼痛、关节肿胀、关节功能障碍评分、28个关节疾病活动度(DAS28)及相关生化指标水平，包括红细胞沉降率(ESR)、类风湿因子(RF)和C反应蛋白(CRP)等，统计总有效率并记录不良反应发情况。结果实验组关节晨僵持续时间、关节压痛、关节肿胀、关节功能障碍、关节疼痛评分、ESR,RF、CRP、DAS28评分显著低于对照组(P<0.05)。结论针对老年RA患者，采用益赛普与甲氨蝶呤片联合应用可提升治疗效果并降低不良反应发生率。

引用

页码：1123 / 1126

页数：4

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