Bcl-2/Bax比率与细胞“命运”

被引：148

作者：

王卫东

陈正堂

机构：

[1] 第三军医大学新桥医院肿瘤科

来源：

中国肿瘤生物治疗杂志 | 2007年 / 04期

关键词：

Bcl-2; Bax; 比率; 细胞凋亡;

D O I：

暂无

中图分类号：

R730.2 [肿瘤病理学、病因学]; R730.5 [肿瘤治疗学];

学科分类号：

100214 ;

摘要：

凋亡过程的启动直接决定了细胞的"命运"。在细胞凋亡的两个进化保守的信号转导途径中,Bcl-2家族成员的构成比例是凋亡调控的关键因素,尤其是Bcl-2/Bax比率是启动细胞凋亡的"分子开关"。Bax和Bcl-2通过形成同源或异源二聚体来调节细胞凋亡:当Bax形成同源二聚体时诱导细胞凋亡;Bax与bcl-2形成异源二聚体时则抑制细胞凋亡。当某细胞系的所有细胞内异源二聚体(Bcl-XL/Bax和Bcl2/Bax)的含量≥50%时,细胞耐受凋亡;而当细胞内Bax同源二聚体>80%时,且在适当信号诱导下则细胞出现凋亡。细胞凋亡的数学模型认为,Bcl-2家族之促凋亡和抑凋亡成员的比率直接决定了线粒体外膜各种通道的开放程度,形成细胞凋亡调控的枢纽;故有学者认为Bcl-2/Bax比率是调控细胞死亡的"可变电阻器"(rheo-stat),在外界因素刺激下,细胞的生死最终取决于Bc-2和Bax两种调控因子的平衡结果。目前关于前列腺癌、直肠癌、白血病、宫颈癌等的临床研究均支持这一理论。

引用

页码：393 / 396

页数：4

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