转化生长因子β1基因多态性与结直肠癌的相关性分析

被引:2
作者
付娟
杨欣
罗爱华
姚霞
欧宝权
尹宜发
机构
[1] 湖北省宜昌市第二人民医院放化疗科
关键词
结肠肿瘤; 转化生长因子-β1; 单核苷酸多态性;
D O I
10.13455/j.cnki.cjcor.2016.01.09
中图分类号
R735.34 [];
学科分类号
摘要
目的分析转化生长因子β1(TGF-β1)基因多态性与结直肠癌的相关性。方法选取2008年1月至2013年1月间诊治的109例结直肠癌患者为观察组,120例健康体检者作为对照组。分析对比两组TGF-β1基因多态性及其与结直肠癌的相关性。结果两组TGF-β1 869C及869T等位基因频率差异无统计学意义(P>0.05)。观察组患者TGF-β1的509T等位基因频率显著高于对照组(χ2=6.109,P=0.013)。Logistic回归分析显示,携带TGF-β1(509T)基因是发生结直肠癌的独立危险因素(OR=3.512,95%CI为2.136~5.641)。结论 TGF-β1 509基因与结直肠癌发病相关,其T等位基因可能是结直肠癌发病的危险因素。
引用
收藏
页码:33 / 35
页数:3
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