脑卒中后抑郁患者抗抑郁治疗磁共振波谱分析研究

被引:8
作者
黄延焱
吴晓琰
朱珍
施小梅
耿道颖
机构
[1] 上海复旦大学上海医学院附属华山医院老年病科
[2] 上海复旦大学附属儿科医院放射科
[3] 上海复旦大学附属华山医院放射科 上海
[4] 上海
关键词
脑卒中; 抑郁症状; 核磁波谱分析;
D O I
暂无
中图分类号
R749.13 [];
学科分类号
100205 ;
摘要
目的利用MRS技术研究影像学与脑卒中后抑郁(PSD)的关系。方法PSD组30例,符合DSMIV抑郁症状学、严重程度和病程标准。正常老年对照组20例。给予颅MRI、MRS检查。PSD组给予帕罗西汀(20~40)mg·qd。半年后随访颅MRI、MRS。结果PSD组患者双侧颞叶、丘脑NAA/Cr比值、Cho/Cr比值与正常对照组相比,存在统计学差异(P<005、P<001)。PSD组双侧Cho/Cr比值呈不对称性,左侧大于右侧(P<001)。PSD组汉密顿抑郁量表(HAMD)评分与左右颞叶Cho/Cr比值存在相关性(r左=0454,P=0012;r右=0373,P=0042)。PSD组患者在给予抗抑郁药物治疗后其双侧颞叶、丘脑NAA/Cr比值、Cho/Cr比值均有不同程度的下降(P<005);相关分析发现HAMD各因子分及总评分下降的程度与双侧颞叶、丘脑NAA/Cr、Cho/Cr比值下降程度之间不存在相关性。结论对脑卒中患者同时行MRI、MRS检查,测定双侧颞叶、丘脑Cho/Cr比值可以帮助早期判别PSD。
引用
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页码:48 / 50
页数:3
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