基质金属蛋白酶与支气管哮喘气道重塑

被引：1

作者：

叶新民 ^{[1
,2
]}

钟南山 ^{[3
]}

机构：

[1] 南京儿童医院呼吸科

[2] 广州医学院

[3] 广州医学院第一附属医院广州呼吸疾病研究所

来源：

国际呼吸杂志 | 2009年 / 11期

关键词：

基质金属蛋白酶; 哮喘; 气道重塑;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

气道炎症和重塑是支气管哮喘(简称哮喘)的主要特征。细胞外基质(extracellular matrix,ECM)的降解和沉积失衡是导致呼吸道壁结构异常构建的重要原因,而基质金属蛋白酶(matrixmetalloproteinases,MMP)则是调节ECM代谢的主要限速酶。各种MMP及其抑制剂之间可以互相调节,也可作用于细胞因子等多种炎症因子,以增强或减弱其生物学效应。气道重塑的过程也是MMP在气道壁沉积的过程,因此对MMP及其抑制剂的深入研究,对哮喘炎症及气道重塑机制的进一步明确有着重要意义。本文着重就MMP的生物学特性以及它们在哮喘气道重塑中所起的作用进行综述。

引用

页码：672 / 676

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