上皮紧密连接与炎性肠病的研究进展

被引:17
作者
蔡文娟
章明放
机构
[1] 天津市第一中心医院病理科
关键词
炎性肠病; 肠上皮屏障; 细胞间紧密连接;
D O I
暂无
中图分类号
R363 [病理生理学];
学科分类号
100103 [病原生物学];
摘要
炎症性肠病(IBD)主要是一组反复发作的慢性非特异性肠道炎症性疾病,包括克罗恩病和溃疡性结肠炎。IBD发病时,肠黏膜屏障功能异常,抗原移位刺激免疫细胞,产生大量炎性细胞因子及介质,炎性分子破坏紧密连接,加剧损伤肠黏膜屏障功能。通过保护肠上皮细胞骨架、修复上皮细胞及细胞间紧密连接能改善肠上皮屏障功能,这也是当前临床治疗IBD的新策略和新思路。
引用
收藏
页码:2274 / 2276
页数:3
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