从细胞因子角度看肿瘤微环境对免疫细胞及肿瘤细胞的影响附视频

被引：28

作者：

王姗 ^{[1
]}

郑金华 ^{[2
]}

孟琰 ^{[1
]}

孙长生 ^{[1
]}

王鑫 ^{[1
]}

苏艳国 ^{[1
]}

赵尔杨 ^{[1
]}

机构：

[1] 哈尔滨医科大学第一临床医学院,口腔医学院,口腔病理教研室

[2] 哈尔滨医科大学基础医学院解剖教研室

来源：

肿瘤学杂志 | 2015年 / 03期

关键词：

免疫细胞; 肿瘤细胞; 肿瘤微环境; 细胞因子;

D O I：

暂无

中图分类号：

R730.5 [肿瘤治疗学];

学科分类号：

100214 [肿瘤学];

摘要：

近年来,肿瘤微环境对肿瘤细胞影响的研究逐渐深入,肿瘤微环境可以通过多种途径影响肿瘤细胞的变化,此变化过程与细胞因子密切相关。细胞因子来自肿瘤微环境中的免疫细胞和肿瘤细胞,在体内通过多种方式参与肿瘤的演进转归过程,发挥协同或拮抗效应。尽管它们自身并不具备明确的抗瘤或者抑瘤能力,但却是肿瘤微环境与肿瘤细胞信息交换的桥梁。因此针对细胞因子的合理引导可能是抗肿瘤免疫治疗的重要环节。文章就细胞因子影响微环境中免疫细胞变化以及加强肿瘤细胞遗传不稳定性并破坏肿瘤细胞DNA的机制进行综述。

引用

页码：237 / 241

页数：5

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