丙泊酚对电离辐射引起小鼠造血系统损伤的防护作用

被引：4

作者：

韩晓亮

蒲国华

李宝永

董微

姚美

机构：

[1] 华北理工大学附属医院麻醉科

来源：

国际药学研究杂志 | 2016年 / 43卷 / 05期

关键词：

丙泊酚; 电离辐射; 造血系统;

D O I：

10.13220/j.cnki.jipr.2016.05.023

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

目的观察丙泊酚对电离辐射引起造血系统损伤防护作用。方法实验采用3种照射剂量:生存率实验照射剂量为7.5 Gy、脾结节形成实验照射剂量为6 Gy、外周血细胞计数和骨髓单侧股骨细胞计数实验照射剂量为2 Gy;生存率实验分为4组:7.5Gy组、7.5Gy+5 mg/kg丙泊酚组、7.5Gy+10 mg/kg丙泊酚组、7.5Gy+20 mg/kg丙泊酚组。其余实验分为4组:对照组、丙泊酚20 mg/kg组、照射组(2Gy或6Gy)、照射+丙泊酚20 mg/kg组。给药方式为照射前1 d、照射当天提前30 min各给药一次和照射后7 d连续腹腔注射,每日1次,照射后第9天活杀小鼠,检测脾结节形成数,各类外周血细胞数及单侧股骨骨髓细胞数。结果丙泊酚20 mg/kg能提高受照射小鼠30 d生存率,增加受照射小鼠脾结节形成数、增加受照射小鼠外周血白细胞数、红细胞数、血红蛋白含量及小鼠单侧股骨骨髓有核细胞数,与照射对照组比较,结果有统计学意义(P<0.05)。结论丙泊酚对电离辐射引起的造血系统损伤均有保护作用,其作用机制有待进一步研究。

引用

页码：931 / 934

页数：4

共 9 条

[1] 抗辐射生物药物的研究进展 [J].

石童 ;

王陈 ;

蒋辉 ;

李丽琴 ;

陈冀胜 .

国际药学研究杂志, 2014, 41 (06) :658-662

[2]

The assessment of WWTP performance: Towards a jigsaw puzzle evaluation?[J] . Matteo Papa,Elisabetta Ceretti,Gaia Claudia Viviana Viola,Donatella Feretti,Ilaria Zerbini,Giovanna Mazzoleni,Nathalie Steimberg,Roberta Pedrazzani,Giorgio Bertanza.Chemosphere . 2016

[3]

Metformin ameliorates ionizing irradiation-induced long-term hematopoietic stem cell injury in mice[J] . Guoshun Xu,Hongying Wu,Junling Zhang,Deguan Li,Yueying Wang,Yingying Wang,Heng Zhang,Lu Lu,Chengcheng Li,Song Huang,Yonghua Xing,Daohong Zhou,Aimin Meng.Free Radical Biology and Medicine . 2015

[4]

Propofol Attenuates Small Intestinal Ischemia Reperfusion Injury through Inhibiting NADPH Oxidase Mediated Mast Cell Activation[J] . Xiaoliang Gan,Dandan Xing,Guangjie Su,Shun Li,Chenfang Luo,Michael G. Irwin,Zhengyuan Xia,Haobo Li,Ziqing Hei,Mengzhou Xue.Oxidative Medicine and Cellular Longevity . 2015

[5] Propofol alleviates liver oxidative stress via activating Nrf2 pathway [J].

Ge, Mian ;

Yao, Weifeng ;

Wang, Yanling ;

Yuan, Dongdong ;

Chi, Xinjin ;

Luo, Gangjian ;

Hei, Ziqing .

JOURNAL OF SURGICAL RESEARCH, 2015, 196 (02) :373-381

[6]

Protective effects of propofol against Methamphetamine-induced neurotoxicity[J] . Mohammad Shokrzadeh,Ehsan Zamani,Mona Mehrzad,Yazdan Norian,Fatemeh Shaki.Toxicology International . 2015 (1)

[7]

Resveratrol ameliorates ionizing irradiation-induced long-term hematopoietic stem cell injury in mice[J] . Heng Zhang,Zhibin Zhai,Yueying Wang,Junling Zhang,Hongying Wu,Yingying Wang,Chengcheng Li,Deguan Li,Lu Lu,Xiaochun Wang,Jianhui Chang,Qi Hou,Zhenyu Ju,Daohong Zhou,Aimin Meng.Free Radical Biology and Medicine . 2013

[8]

Vaccines using dendritic cells, differentiated with propofol, enhance antitumor immunity in mice[J] . Takefumi Inada,Kozue Kubo,Koh Shingu.Immunopharmacology and Immunotoxicology . 2009 (1)

[9]

Propofol Suppresses Prostaglandin E2 Production in Human Peripheral Monocytes[J] . Tomoko Kambara,Takefumi Inada,Kozue Kubo,Koh Shingu.Immunopharmacology and Immunotoxicology . 2009 (1)

← 1 →