基于突触可塑性的疼痛研究及临床转化

被引:12
作者
张小飞
刘菊英
机构
[1] 湖北医药学院附属太和医院麻醉科,十堰
关键词
疼痛; 脊髓; 前扣带回皮质; 突触可塑性; 树突棘; 长时程增强; 长时程减弱;
D O I
暂无
中图分类号
R402 [];
学科分类号
摘要
疼痛是一种复杂的生理心理活动, 常伴随各种疾病, 由于其病因多样、发病机制复杂且尚不明确, 而成为亟待解决的科学难题。文章主要阐述在疼痛发生过程中突触可塑性改变的研究进展、疼痛信号的转导与突触可塑性改变, 以及突触结构可塑性、功能可塑性在疼痛中的作用, 并对基于突触可塑性的疼痛治疗进行综述, 旨在更好地认识疼痛机制并对其后续的治疗提供思路, 以求为临床疼痛治疗提供更为可靠的证据。
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