抗糖尿病肽类药物研究进展

被引：8

作者：

严国文

李谦

何书英

朱杰

吴梧桐

机构：

[1] 中国药科大学生命科学与技术学院

来源：

药物生物技术 | 2012年 / 19卷 / 03期

基金：

中央高校基本科研业务费专项资金资助;

关键词：

糖尿病; 降血糖药物; 肽; 胰高血糖素样肽-1; 艾塞那肽; 胰淀素; 抗糖尿病寡肽;

D O I：

10.19526/j.cnki.1005-8915.2012.03.020

中图分类号：

R977.15 [];

学科分类号：

摘要：

糖尿病是以胰岛素相对或绝对不足为特征的代谢性疾病,严重危害人类健康,传统抗糖尿病药物各有缺点,从而催生了抗糖尿病肽类药物的面世。常见于文献报道的抗糖尿病肽有胰高血糖素样肽-1(Glucagon-like peptide-1,GLP-1)受体激动剂、基于胰淀素开发的抗糖尿病肽、动植物来源的抗糖尿病肽和抗糖尿病寡肽,其中前者又包括GLP-1衍生物和GLP-1类似物。该文对它们各自的优缺点,研发思路和药理效应作了综述。

引用

页码：270 / 273

页数：4

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