血红素加氧酶-1与心血管疾病研究进展

被引:3
作者
朱凯媛
蔡辉
机构
[1] 南京军区南京总医院中西医结合科
关键词
血红素加氧酶-1; 心血管疾病; 综述;
D O I
暂无
中图分类号
R54 [心脏、血管(循环系)疾病];
学科分类号
100201 [内科学];
摘要
<正>血红素加氧酶-1(Heme oxygenase,HO-1)是一种32 kDa蛋白,最早在1968年被确定为有降解血红素能力的微粒体酶[1],多个研究支持HO-1在心血管系统中的作用,包括调节血管张力、抗凋亡和血管生成。HO-1缺乏与活性氧簇(reactive oxygen apecies,ROS)损伤、慢性炎症相关,也与增加心血管疾病易感性相关。HO-1可被多种物理和化学应力诱导,产生保护作用。笔者就HO-1的生物特性、基因表达调控、代谢产物以及在多种心血管疾病中的研究进展作一综述。
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