IFN-γ介导的抗弓形虫作用及其作用机理

被引:9
作者
张君
于三科
机构
[1] 青海省畜牧兽医科学院!西宁
[2] 西北农林科技大学动物科学与动物医学学院
关键词
弓形虫; IFN-γ; 免疫机理;
D O I
10.16437/j.cnki.1007-5038.2000.01.007
中图分类号
S852.71 [兽医临床寄生虫学];
学科分类号
090601 ;
摘要
弓形虫是世界范围内分布的人兽共患寄生原虫 ,其免疫机理以细胞介导免疫为主。IFN- γ是细胞介导免疫的重要免疫分子 ,通过阐述 IFN- γ介导抗弓形虫作用及其作用机理 ,指出 IFN-γ可诱导免疫细胞活化 ,介导机体免疫细胞抑制弓形虫增殖 ,杀伤细胞内弓形虫。其抗虫作用主要通过活化巨噬细胞产生超氧离子 ,精氨酸依赖的 NO途径活化巨噬细胞 ,诱导降解色氨酸等途径 ,抑制了弓形虫的增殖。
引用
收藏
页码:25 / 27+38 +38
页数:4
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