痛风治疗新药研究进展

被引：28

作者：

涂彩霞

刘旭

李玲

牛艳芬

机构：

[1] 昆明医科大学生物医学工程研究中心

来源：

国际药学研究杂志 | 2016年 / 43卷 / 05期

关键词：

痛风; 高尿酸血症; 黄嘌呤氧化还原酶; 尿酸酶; 尿酸转运体;

D O I：

10.13220/j.cnki.jipr.2016.05.009

中图分类号：

R977 [影响生长代谢机能药物];

学科分类号：

100710 [药物代谢动力学];

摘要：

痛风的发病率在世界范围内呈逐年上升趋势,并且与高血压、高脂血症、动脉粥样硬化、肥胖和胰岛素抵抗等疾病的发生密切相关,是当今世界尤其是中老年男性的常见病,已成为威胁人类健康的严重代谢性疾病。目前治疗痛风的药物倍受关注,主要包括以嘌呤代谢关键酶为靶点的降尿酸药物、以肾小管尿酸转运体为靶点的降尿酸药物、黄嘌呤氧化还原酶和肾小管尿酸转运体的双重抑制剂及尿酸氧化酶等4种类型。本文概括了痛风治疗新药研究进展。

引用

页码：858 / 862

页数：5

共 13 条

[1]

抗高尿酸血症药物研究进展 [J].

刘永贵 ;

赵丽嘉 ;

崔艳丽 ;

贺星 ;

沈雪砚 ;

陈常青 .

现代药物与临床, 2015, 30 (03) :345-350

[2]

New medications in development for the treatment of hyperuricemia of gout [J].

Diaz-Torne, Cesar ;

Perez-Herrero, Nuria ;

Perez-Ruiz, Fernando .

CURRENT OPINION IN RHEUMATOLOGY, 2015, 27 (02) :164-169

[3]

Risk of Anaphylaxis with Repeated Courses of Rasburicase: A Research on Adverse Drug Events and Reports (RADAR) Project [J].

Allen, Katherine C. ;

Champlain, Amanda H. ;

Cotliar, Jonathan A. ;

Belknap, Steven M. ;

West, Dennis P. ;

Mehta, Jayesh ;

Trifilio, Steven M. .

DRUG SAFETY, 2015, 38 (02) :183-187

[4]

Emerging Therapies for Gout [J].

Edwards, N. Lawrence ;

So, Alexander .

RHEUMATIC DISEASE CLINICS OF NORTH AMERICA, 2014, 40 (02) :375-+

[5]

Febuxostat: drug review and update [J].

Grewal, Harmanjot K. ;

Martinez, Joseph R. ;

Espinoza, Luis R. .

EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, 2014, 10 (05) :747-758

[6]

Recent advances in understanding and managing adenosine deaminase and purine nucleoside phosphorylase deficiencies [J].

Grunebaum, Eyal ;

Cohen, Amos ;

Roifman, Chaim M. .

CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, 2013, 13 (06) :630-638

[7]

Population-specific influence of SLC2A9 genotype on the acute hyperuricaemic response to a fructose load [J].

Dalbeth, Nicola ;

House, Meaghan E. ;

Gamble, Gregory D. ;

Horne, Anne ;

Pool, Bregina ;

Purvis, Lauren ;

Stewart, Angela ;

Merriman, Marilyn ;

Cadzow, Murray ;

Phipps-Green, Amanda ;

Merriman, Tony R. .

ANNALS OF THE RHEUMATIC DISEASES, 2013, 72 (11) :1868-1873

[8]

2012 American College of Rheumatology guidelines for management of gout. Part 1: Systematic nonpharmacologic and pharmacologic therapeutic approaches to hyperuricemia [J].

Khanna, Dinesh ;

Fitzgerald, John D. ;

Khanna, Puja P. ;

Bae, Sangmee ;

Singh, Manjit K. ;

Neogi, Tuhina ;

Pillinger, Michael H. ;

Merill, Joan ;

Lee, Susan ;

Prakash, Shraddha ;

Kaldas, Marian ;

Gogia, Maneesh ;

Perez-Ruiz, Fernando ;

Taylor, Will ;

Liote, Frederic ;

Choi, Hyon ;

Singh, Jasvinder A. ;

Dalbeth, Nicola ;

Kaplan, Sanford ;

Niyyar, Vandana ;

Jones, Danielle ;

Yarows, Steven A. ;

Roessler, Blake ;

Kerr, Gail ;

King, Charles ;

Levy, Gerald ;

Furst, Daniel E. ;

Edwards, N. Lawrence ;

Mandell, Brian ;

Schumacher, H. Ralph ;

Robbins, Mark ;

Wenger, Neil ;

Terkeltaub, Robert .

ARTHRITIS CARE & RESEARCH, 2012, 64 (10) :1431-1446

[9]

Recent advances in renal urate transport: characterization of candidate transporters indicated by genome-wide association studies [J].

Anzai, Naohiko ;

Jutabha, Promsuk ;

Amonpatumrat-Takahashi, Sirirat ;

Sakurai, Hiroyuki .

CLINICAL AND EXPERIMENTAL NEPHROLOGY, 2012, 16 (01) :89-95

[10]

Methemoglobinemia and hemolysis in a patient with G6PD deficiency treated with rasburicase.[J].Mohamad Bassam Sonbol;Hemang Yadav;Rakhee Vaidya;Vishal Rana;Thomas E. Witzig.Am. J. Hematol.2012, 2

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