姜黄素治疗银屑病临床疗效观察及对NF-kappaB活化的影响

被引:8
作者
张颖鹏
刘志刚
任诗峰
曾磊
机构
[1] 南昌大学第二附属医院皮肤科
关键词
姜黄素; 银屑病; 核因子-κB;
D O I
暂无
中图分类号
R758.63 [牛皮癣(银屑病)];
学科分类号
100206 ;
摘要
目的探讨姜黄素治疗银屑病疗效及其对核因子-κB活化的影响。方法应用姜黄素治疗银屑病30例患者。治疗前和治疗2个月后详细记录皮损情况并观察不良反应,进行PASI评分。提取皮损组织的mRNA,以RT-PCR法检测标本中NF-κB mRNA的表达。结果采用姜黄素治疗2个月后银屑病患者PASI评分明显降低,治疗期间无明显不良反应,且姜黄素能显著抑制银屑病皮损组织NF-κB mRNA的表达。结论姜黄素治疗银屑病安全有效,可能通过抑制NF-κB表达起作用。
引用
收藏
页码:944 / 946
页数:3
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