蒽环类药物在多药抗药细胞株K562r细胞内的积聚、滞留与外排

被引:7
作者
胡汛
陈万源
机构
[1] 浙江医科大学肿瘤研究所
[2] 浙江医科大学肿瘤研究所 杭州 中国
[3] 杭州
关键词
阿霉素; 表阿霉素; 柔红霉素; 高压液相色谱法; 抗药性; 维拉帕米;
D O I
暂无
中图分类号
R96 [药理学];
学科分类号
100602 ; 100706 ;
摘要
我们建立的抗药细胞株K 562r表现为典型的MDR特性,K 562r细胞对阿霉素、表阿霉素、及柔红霉素的摄入量减少,外排量增加。维拉帕米对K 562r细胞的药物摄取无明显影响,但能抑制K 562r细胞内的药物外排,摄取药物60min时,1×10~6K 562r细胞核中阿霉素、表阿霉素和柔红霉素的含量分别为809±68,1238±81和1664±77 ng,显著低于K562r细胞核内的药物含量P<0.01。
引用
收藏
页码:85 / 89
页数:5
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