代谢性炎症在骨关节炎发病机制中的作用

被引:24
作者
何凡
丁长海
徐建华
机构
[1] 安徽医科大学第一附属医院风湿免疫科
关键词
D O I
暂无
中图分类号
R684.3 [关节炎];
学科分类号
100220 [骨科学];
摘要
<正>骨关节炎(osteoarthritis)是最常见的一种关节炎,是老年人关节致残的主要原因。骨关节炎的危险因素包括女性、年龄、肥胖、遗传、外伤、关节承重等,其发病机制尚不清楚,传统的观念认为,骨关节炎是关节软骨的退行性变,非炎症因子参与;近年来研究发现,代谢性炎症及炎症因子在骨关节炎发病中起着重要作用,现综述如下。1代谢性炎症的概念过去认为白色脂肪组织只具有简单的能量存储功能,近年来研究表明,白色脂肪组织活化增加了促炎症细胞因子如
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