遗传与环境因素在炎症性肠病发病机制中的作用研究

被引:64
作者
艾静 [1 ,2 ]
王承党 [1 ,2 ]
机构
[1] 福建医科大学附属第一医院消化内科
[2] 福建医科大学消化系疾病研究室
关键词
炎症性肠病; 溃疡性结肠炎; 克罗恩病; 遗传; 环境;
D O I
暂无
中图分类号
R574.62 [结肠疾病];
学科分类号
100201 [内科学];
摘要
炎症性肠病(IBD)的病因和发病机制尚未完全明确,遗传和环境被认为是重要因素。近年来,随着中国经济的发展,IBD的发病率和患病率也明显上升,似乎环境因素发挥了重要的作用。在IBD发病机制中,是遗传因素还是环境因素起了关键的作用?此文就此作一综述分析。
引用
收藏
页码:110 / 113
页数:4
相关论文
共 23 条
[1]
Molecular function of macrophage migration inhibitory factor and a novel therapy for inflammatory bowel disease.[J].Jun Nishihira.Annals of the New York Academy of Sciences.2012, 1
[2]
Regulation of epithelial barrier function by the inflammatory bowel disease candidate gene; PTPN2.[J].Declan F. McCole.Annals of the New York Academy of Sciences.2012, 1
[3]
Current smoking differentially affects blood mononuclear cells from patients with crohn's disease and ulcerative colitis: Relevance to its adverse role in the disease [J].
Bergeron, Vivianne ;
Grondin, Virginie ;
Rajca, Sylvie ;
Maubert, Marie-Anne ;
Pigneur, Benedicte ;
Thomas, Ginette ;
Trugnan, Germain ;
Beaugerie, Laurent ;
Cosnes, Jacques ;
Masliah, Joelle ;
Sokol, Harry ;
Seksik, Philippe ;
Bachelet, Maria .
INFLAMMATORY BOWEL DISEASES, 2012, 18 (06) :1101-1111
[4]
Role of genetic and environmental factors in British twins with inflammatory bowel disease [J].
Ng, Siew C. ;
Woodrow, Susannah ;
Patel, Nisha ;
Subhani, Javaid ;
Harbord, Marcus .
INFLAMMATORY BOWEL DISEASES, 2012, 18 (04) :725-736
[5]
Risk factors in German twins with inflammatory bowel disease: Results of a questionnaire-based survey.[J].Martina E. Spehlmann;Alexander Z. Begun;Ekaterini Saroglou;Frank Hinrichs;Ute Tiemann;Andreas Raedler;Stefan Schreiber.Journal of Crohn's and Colitis.2011, 1
[6]
Contribution of the -173 G/C Polymorphism of Macrophage Migration Inhibitory Factor Gene to the Risk of Inflammatory Bowel Diseases.[J].Karolina Przyby?owska;Jerzy Mrowicki;Andrzej Sygut;Piotr Narbutt;?ukasz Dziki;Adam Dziki;Ireneusz Majsterek.Polish Journal of Surgery.2011, 2
[7]
Environmental risk factors in inflammatory bowel diseases. Investigating the hygiene hypothesis: A Spanish case–control study.[J].Pilar López-Serrano;José L. Pérez-Calle;Maria Teresa Pérez-Fernández;Juan Manuel Fernández-Font;Daniel Boixeda de Miguel;Conrado M. Fernández-Rodríguez.Scandinavian Journal of Gastroenterology.2010, 12
[8]
Progression of inflammatory bowel disease in China [J].
Wang, Yu Fang ;
Ouyang, Qin ;
Hu, Ren Wei .
JOURNAL OF DIGESTIVE DISEASES, 2010, 11 (02) :76-82
[9]
Contribution of rs11465788 in IL23R gene to Crohn's disease susceptibility and phenotype in Chinese population [J].
Chen Bin ;
Zeng Zhirong ;
Wu Xiaoqin ;
Chen Minhu ;
Li Mei ;
Gao Xiang ;
Chen Baili ;
Hu Pinjin .
JOURNAL OF GENETICS, 2009, 88 (02) :191-196
[10]
Is there a link between food and intestinal microbes and the occurrence of Crohn's disease and ulcerative colitis? [J].
Asakura, Hitoshi ;
Suzuki, Kenji ;
Kitahora, Tetsuji ;
Morizane, Toshio .
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2008, 23 (12) :1794-1801