SOCS-3在瘦素抵抗及肥胖发病中的作用

被引:3
作者
曲伸
邹大进
机构
[1] 第二军医大学长海医院内分泌科
[2] 第二军医大学长海医院内分泌科 上海
[3] 上海
关键词
细胞因子转导抑制物; 瘦素; 肥胖; 综述文献;
D O I
10.16781/j.0258-879x.2003.09.038
中图分类号
R589.2 [脂肪代谢障碍];
学科分类号
1002 ; 100201 ;
摘要
细胞因子信号转导抑制物 (suppressorofcytokinesignaling ,SOCS)是一组抑制JAK STAT信号转导的蛋白 ,在体内可抑制多种细胞因子的信号转导 ,包括瘦素的转导。目前认为 ,SOCS 3增多是瘦素抵抗的标志 ,并与肥胖的发病有明显的相关性。本文对SOCS的结构与功能及其在瘦素信号转导中的作用机制进行综述 ,探讨SOCS在肥胖发病中的作用
引用
收藏
页码:1026 / 1028
页数:3
相关论文
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