慢性炎症、肿瘤微环境与癌变

被引:56
作者
Tamas AGonda [1 ,2 ,3 ,4 ]
Shuiping Tu [1 ,2 ,3 ,4 ]
Timothy CWang [1 ,2 ,3 ,4 ]
丁燕 [5 ]
南娟 [5 ]
机构
[1] Division of Digestive and Liver Diseases
[2] Department of Medicine
[3] Irving Cancer Research Center
[4] Columbia University
[5] 天津医科大学总医院,天津市肺癌研究所,天津市肺癌转移与肿瘤微环境重点实验室
关键词
慢性炎症; 肿瘤微环境; 骨髓源细胞; 胃癌; 肌成纤维细胞; 髓源性抑制细胞;
D O I
暂无
中图分类号
R730.2 [肿瘤病理学、病因学];
学科分类号
100214 [肿瘤学];
摘要
<正>某些肿瘤发生前或发生时常有慢性炎症。抗炎疗法在癌症的预防及治疗中也显现出一定的疗效。创伤愈合演变为癌症前兆的具体机理已成为当前研究的热点。已有研究证实,炎症介质、炎症相关基因多态性与癌变之间存在病
引用
收藏
页码:1022 / 1031
页数:10
相关论文
共 20 条
[1]
IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer[J] Sergei Grivennikov;Eliad Karin;Janos Terzic;Daniel Mucida;Guann-Yi Yu;Sivakumar Vallabhapurapu;Jürgen Scheller;Stefan Rose-John;Hilde Cheroutre;Lars Eckmann;Michael Karin Cancer Cell 2009,
[2]
gp130-Mediated Stat3 Activation in Enterocytes Regulates Cell Survival and Cell-Cycle Progression during Colitis-Associated Tumorigenesis[J] Cancer Cell 2009,
[3]
Alterations of DNA methylation and clinicopathological diversity of human cancers[J] YaeKanai Pathology International 2008,
[4]
Overexpression of Interleukin-1β Induces Gastric Inflammation and Cancer and Mobilizes Myeloid-Derived Suppressor Cells in Mice[J] Shuiping Tu;Govind Bhagat;Guanglin Cui;Shigeo Takaishi;Evelyn A. Kurt-Jones;Barry Rickman;Kelly S. Betz;Melitta Penz-Oesterreicher;Olle Bjorkdahl;James G. Fox;Timothy C. Wang Cancer Cell 2008,
[5]
Matrix Metalloproteinase-9 Is Required for Tumor Vasculogenesis but Not for Angiogenesis: Role of Bone Marrow-Derived Myelomonocytic Cells[J] G-One Ahn;J. Martin Brown Cancer Cell 2008,
[6]
Microenvironmental regulation of cancer development[J] Min Hu;Kornelia Polyak Current Opinion in Genetics & Development 2008,
[7]
Epigenetic Changes Induced by Reactive Oxygen Species in Hepatocellular Carcinoma: Methylation of the E-cadherin Promoter[J] Seung-Oe Lim;Jin-Mo Gu;Min Sook Kim;Hyun-Soo Kim;Young Nyun Park;Cheol Keun Park;Jae Won Cho;Young Min Park;Guhung Jung Gastroenterology 2008,
[8]
Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage; metastatic tumor burden; and doxorubicin–cyclophosphamide chemotherapy[J] C. Marcela Diaz-Montero;Mohamed Labib Salem;Michael I. Nishimura;Elizabeth Garrett-Mayer;David J. Cole;Alberto J. Montero Cancer Immunology; Immunotherapy 2009,
[9]
Inflammatory cell infiltration of tumors: Jekyll or Hyde[J] James E. Talmadge;Moses Donkor;Eric Scholar Cancer and Metastasis Reviews 2007,
[10]
Inflammation and cancer: An ancient link with novel potentials[J] S.Perwez Hussain;Curtis C.Harris Int. J. Cancer 2007,