肿瘤坏死因子受体相关因子参与炎症免疫调节的研究进展

被引：50

作者：

李影

陈镜宇

张玲玲

魏伟

机构：

[1] 安徽医科大学临床药理研究所抗免疫药物教育部重点实验室

来源：

中国药理学通报 | 2015年 / 09期

基金：

中国博士后科学基金;

关键词：

TRAF; 信号转导; TNFR; NF-κB; 免疫; 炎症; 疾病;

D O I：

暂无

中图分类号：

R363 [病理生理学];

学科分类号：

100103 [病原生物学];

摘要：

肿瘤坏死因子受体相关因子(tumor necrosis factor receptor-associated factors,TRAF)是一类重要的具有多功能的细胞内信号转导因子。TRAF参与多种受体家族的信号转导,包括肿瘤坏死因子受体家族(tumor necrosis factor receptor,TNFR)和Toll样-IL-1受体(Toll-like receptors-interleukin-1 receptors,TLR-IL-1R)家族等,在固有免疫和获得性免疫中发挥重要作用。受体活化时,TRAF直接或间接募集下游受体的胞内结构域,参与信号转导,最终激活NF-κB和干扰素调节因子(interferon regulatory factor,IRF)等活化转录因子信号通路,从而诱导免疫和炎症反应,参与炎症免疫性疾病的发生发展。

引用

页码：1206 / 1211

页数：6

共 12 条

[1]

树突细胞在类风湿性关节炎病理机制中的免疫原性和耐受性双重作用 [J].

付静静 ;

张玲玲 ;

魏伟 .

中国药理学通报, 2012, (09) :1185-1188

[2]

TRAF-mediated modulation of NF-kB AND JNK Activation by TNFR2[J] Lucía Cabal-Hierro;Montserrat Rodríguez;Noelia Artime;Julián Iglesias;Lorea Ugarte;Miguel A. Prado;Pedro S. Lazo Cellular Signalling 2014,

[3]

Protein kinase C-associated kinase regulates NF-κB activation throughinducing IKK activation[J] Sang-Woo Kim;Matthew Schifano;David Oleksyn;Craig Jordan;Daniel Ryan;Richard Insel;Jiyong Zhao;Luojing Chen International Journal of Oncology 2014,

[4]

The TRAF3 adaptor protein drives proliferation of anaplastic large cell lymphoma cells by regulating multiple signaling pathways[J] Israel Muro;Gloria Fang;Kacie Gardella;Indra Mahajan;Casey Wright Cell Cycle 2014,

[5]

Gene set enrichment analysis of the NF-κB/Snail/YY1/RKIP circuitry in multiple myeloma[J] Apostolos Zaravinos;Peggy Kanellou;George Ι. Lambrou;Demetrios A. Spandidos Tumor Biology 2014,

[6]

Structure of the TRAF4 TRAF domain with a coiled-coil domain and its implications for the TRAF4 signalling pathway[J] Jong Hwan Yoon;Young jin Cho;Hyun Ho Park Acta Crystallogr D Biol Crystallogr 2014,

[7]

The E3 ubiquitin ligase TRAF2 can contribute to TNF-α resistance in FLT3-ITD-positive AML cells[J] Ulf Schnetzke;Mike Fischer;Bärbel Spies-Weisshart;Elisabeth Zirm;Andreas Hochhaus;Jörg P. Müller;Sebastian Scholl Leukemia Research 2013,

[8]

Genetic interaction between genes involved in NF-κB signaling pathway in systemic lupus erythematosus[J] Han Cen;Mo Zhou;Rui-Xue Leng;Wei Wang;Chen-Chen Feng;Bao-Zhu Li;Yan Zhu;Xiao-Ke Yang;Mei Yang;Yu Zhai;Min Zhang;Lin-Feng Hu;Rui Li;Gui-Mei Chen;Hong Chen;Hai-Feng Pan;Xiang-Pei Li;Dong-Qing Ye Molecular Immunology 2013,

[9]

Mechanism of focal cerebral ischemic tolerance in rats with ischemicpreconditioning involves MyD88- and TRIF-dependent pathways[J] Li Han;Jin Mingyue;Lv Tao;Guan Junhong Experimental and Therapeutic Medicine 2013,

[10]

Effect of TRAF6 on the biological behavior of human lung adenocarcinoma cell[J] Lou Zhong;Fei Cao;Qingsheng You Tumor Biology 2013,

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