基质金属蛋白酶及其抑制物与支气管哮喘

被引:8
作者
陈径
机构
[1] 东南大学附属中大医院儿科江苏南京
关键词
基质金属蛋白酶; 哮喘;
D O I
暂无
中图分类号
R562.25 [];
学科分类号
1002 ; 100201 ;
摘要
基质金属蛋白酶 (MMPs)是主要的蛋白水解酶之一 ,其活性可以受到内源性抑制物组织金属蛋白酶抑制剂 (TIMPs)特异性调节。MMPs与TIMPs的平衡是维持细胞外基质内环境稳定的决定因素。气道炎症和重构是支气管哮喘的重要特征。MMPs及其抑制物TIMPs可以通过对炎性细胞浸润和功能的影响 ,基质沉积和降解等作用参与支气管哮喘的发病机制 ;并且MMPs与TIMPs比例的失衡与气道高反应性及激素治疗的效果均有密切关系。
引用
收藏
页码:239 / 241
页数:3
相关论文
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