生长抑素联合奥美拉唑对重症急性胰腺炎血清炎性因子与肠道黏膜屏障功能的影响

被引：29

作者：

廖长福

邹世斌

机构：

[1] 自贡市第三人民医院重症医学科

来源：

海南医学院学报 | 2018年 / 24卷 / 24期

关键词：

重症急性胰腺炎; 生长抑素; 奥美拉唑; 炎性因子; 肠道黏膜屏障功能;

D O I：

10.13210/j.cnki.jhmu.20181120.002

中图分类号：

R576 [胰腺疾病];

学科分类号：

100201 [内科学];

摘要：

目的:探讨生长抑素联合奥美拉唑对重症急性胰腺炎血清炎性因子与肠道黏膜屏障功能的影响。方法:选取本院收治的重症急性胰腺炎患者并随机分为两组,对照组接受常规+奥美拉唑治疗,联合组接受常规+生长抑素+奥美拉唑治疗,持续1周。对比两组入院即刻、治疗1周后血清中炎症因子、趋化因子、肠道黏膜屏障功能指标含量的差异。结果:治疗1周后,两组血清中IL-1β、IL-8、IL-18、hs-CRP、MCP-1、FKN、CINC、D-Lactate、DAO、Endotoxin、FABP的含量均明显降低,且观察组治疗后的血清IL-1β、IL-8、IL-18、hs-CRP、MCP-1、FKN、CINC、D-Lactate、DAO、Endotoxin、FABP含量低于对照组。结论:生长抑素联合奥美拉唑治疗重症急性胰腺炎可有效缓解机体炎症反应程度并保护肠道黏膜屏障功能。

引用

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页码：2133 / 2136

页数：4

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