炎性反应在骨关节炎软骨退变中的作用

被引：19

作者：

郑洁 ^{[1
]}

王瑞辉 ^{[1
]}

寇久社 ^{[2
]}

机构：

[1] 陕西中医学院针灸推拿系

[2] 陕西中医学院第二附属医院康复针灸科

来源：

基础医学与临床 | 2014年 / 34卷 / 08期

关键词：

骨关节炎; 炎性反应; 细胞外基质; 软骨细胞; 骨髓间充质干细胞;

D O I：

10.16352/j.issn.1001-6325.2014.08.021

中图分类号：

R684.3 [关节炎];

学科分类号：

100220 [骨科学];

摘要：

慢性炎性反应是骨关节炎软骨破坏的一个主要原因。骨关节炎性环境下,软骨细胞异常活跃,细胞外基质重塑加快,引起软骨细胞生物力学环境的改变,进而推动病理进程。细胞外基质成分和结构的异常改变干扰骨髓间充质干细胞的成软骨分化,从而使软骨的修复无法进行。

引用

页码：1146 / 1149

页数：4

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