抑郁症患者血小板五羟色胺浓度的研究

被引：11

作者：

潘桂花

林治光

李华芳

徐韬园

机构：

[1] 上海市精神卫生中心

来源：

上海精神医学 | 2005年 / 03期

关键词：

抑郁症; 血小板; 五羟色胺; 高效液相色谱法;

D O I：

暂无

中图分类号：

R749.4 [情感性精神病];

学科分类号：

摘要：

目的通过测定抑郁症患者血小板五羟色胺(5-HT)浓度,探讨抑郁症治疗前后5-HT变化及其与临床特征的关系。方法用高效液相色谱法(HPLC)及电化学探测仪测定60例抑郁症患者治疗前后血小板5-HT浓度,并与30名正常者对照比较,同时作相关分析。结果治疗前后抑郁症患者血小板5-HT浓度均显著低于正常对照组(t=5.38,P<0.001;t=3.63,P<0.001);治疗前血小板5-HT浓度与HAMD因子1(焦虑/躯体化)有显著相关性(r=-0.88,P=0.001)。结论抑郁症患者血小板5-HT浓度明显降低,治疗前焦虑/躯体化症状与5-HT浓度呈负相关。

引用

页码：145 / 147+141 +141

页数：4

共 6 条

[1]

D istribution of platelet 5 -HT( 2A) receptor densities in suicidal and non - suicidal depressives and control subjects. A lda M,Hrdina PD. Psychiatry Research . 2000

[2]

clinical and preclinical evidence for the neurotrophic effects ofmood stabilizers: implications for the pathophysiology and treatment ofmanic -depressive illness. ManjiHK,Moore GJ,Chen G. British Journal of Psychiatry . 2000

[3]

Protein kinase A and Rapl levels in platelets of untreated patients with major depression. Perez J,Tardito D,RacagniG,et al. Molecular Psychiatry . 2001

[4]

Serotonergic platelet variables in unmedicated patients suffering form major depression and healthy subjects: relationship between 5HT content and 5HT uptake. Franke L,Schewe HJ,Muller B,et al. Life Sciences . 2000

[5]

Platelets and psychiatry: lessons learned form old and new studies. Camacho A,D imsdale JE. Psychosomatic Medicine . 2000

[6]

Delirum associated with buprop ion. Van Putten T,Shaffer I. Journal of Clinical Psychopharmacology . 1990

← 1 →