黄酮类化合物对醛糖还原酶的抑制作用

被引：15

作者：

谢明智

申竹芳

机构：

[1] 中国医学科学院药物研究所

来源：

关键词：

醛糖还原酶; 醛糖还原酶抑制剂; 黄酮类化合物;

D O I：

10.16438/j.0513-4870.1986.10.001

中图分类号：

学科分类号：

摘要：

本文建立了一个微量、简便、快速的醛糖还原酶抑制剂筛选方法,对32个黄酮类化合物进行了筛选。其中黄芩甙元和异金丝桃甙乙酸盐作用较强,IC50分别为3.5×10-6M及2.2×10-6M。此外,还对其抑制酶的动力学进行了分析。

引用

页码：721 / 724

页数：4

共 8 条

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