自体骨髓基质干细胞动员联合神经生长因子及综合康复治疗脊髓损伤

被引：6

作者：

郭晓鹤 ^{[1
]}

步星耀 ^{[1
]}

闫兆月 ^{[1
]}

马春晓 ^{[1
]}

周伟 ^{[1
]}

周志龙 ^{[1
]}

黄超 ^{[1
]}

钱宝延 ^{[2
]}

机构：

[1] 河南省人民医院神经外科

[2] 河南省人民医院康复科

来源：

中华神经医学杂志 | 2013年 / 12卷 / 08期

关键词：

骨髓基质干细胞; 脊髓损伤; 综合康复;

D O I：

暂无

中图分类号：

R651.2 [脊髓];

学科分类号：

100223 [神经外科学];

摘要：

目的探讨自体骨髓基质干细胞（BMSCs）动员联合神经生长因子及综合康复治疗脊髓损伤（SCI）的临床疗效。方法选择河南省人民医院神经外科自2006年1月至2011年12月收治的SCI患者72例,根据患者意愿分为2组,对照组32例给予神经生长因子和综合康复治疗,治疗组40例在对照组基础上加用自体BMSCs动员治疗。治疗前后依据美国脊髓损伤学会（ASIA）评分、运动诱发电位（MEP）波幅及潜伏期的变化评价疗效,通过流式细胞术检测外周血细胞CD133+CD34+比例,MRI观察SCI治疗前后脊髓的形态学变化,同时观察患者不良反应。结果治疗组患者ASIA评分明显升高,MEP潜伏期明显缩短,波幅明显增高,外周血细胞CD133+CD34+比例升高显著,与对照组比较差异均有统计学意义（P<0.05）。治疗及随访期间均未出现明显不良反应。结论自体BMSCs动员联合神经生长因子及综合康复治疗可有效促进SCI的修复,显著改善患者的神经功能。

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