丹皮酚磺酸钠对钙反常培养乳鼠心肌细胞Ca2+内流的抑制作用

被引:7
作者
唐景荣
石琳
机构
[1] 山东潍坊医学院药理教研室,苏州医学院药理教研室潍坊,苏州
关键词
丹皮酚磺酸钠; 乳鼠心肌细胞; 钙反常; 唾液酸; Ca2+内流;
D O I
10.16438/j.0513-4870.1991.03.001
中图分类号
学科分类号
摘要
培养乳鼠心肌细胞复制钙反常模型,观察丹皮酚磺酸钠对心肌细胞45Ca摄取、膜唾液酸(SA)含量及细胞搏动频率的影响,结果提示丹皮酚磺酸钠在50~400μg/ml范围内能显著抑制正常心肌细胞快相(5 min)和慢相(120 min)45Ca摄取及其搏动频率,且能显著抑制钙反常心肌细胞的45Ca摄取及其胞膜SA含量,与剂量呈正相关,表明丹皮酚磺酸钠减轻钙反常心肌细胞损伤除直接阻止Ca2+内流外,尚与其提高膜SA含量有关。
引用
收藏
页码:161 / 165
页数:5
相关论文
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