化疗致周围神经病变的临床治疗

被引:26
作者
王玉栋
杜玉娟
刘巍
机构
[1] 河北医科大学第四医院肿瘤内科
关键词
化疗; CIPN; 治疗;
D O I
暂无
中图分类号
R730.5 [肿瘤治疗学];
学科分类号
100214 [肿瘤学];
摘要
化疗致周围神经病变(Chemotherapy-induced peripheral neuropathy,CIPN)是常见的化疗相关毒副反应,患者可因不能耐受神经病变所致的疼痛、麻木而中断治疗,影响预后。然而,无论是预防性治疗,还是对症治疗均未显示确切疗效。本文将探讨化疗致周围神经病变的诊断和评估,并对多种正在临床使用的预防性及对症治疗方法进行回顾。
引用
收藏
页码:470 / 474
页数:5
相关论文
共 3 条
[1]
Interleukin-6 protects against paclitaxel, cisplatin and vincristine-induced neuropathies without impairing chemotherapeutic activity [J].
Callizot, Noelle ;
Andriambeloson, Emile ;
Glass, Jonathan ;
Revel, Michel ;
Ferro, Pamela ;
Cirillo, Rocco ;
Vitte, Pierre-Alain ;
Dreano, Michel .
CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2008, 62 (06) :995-1007
[2]
Carbamazepine for prevention of oxaliplatin-related neurotoxicity in patients with advanced colorectal cancer: Final results of a randomised, controlled, multicenter phase II study [J].
von Delius, Stefan ;
Eckel, Florian ;
Wagenpfeil, Stefan ;
Mayr, Martina ;
Stock, Konrad ;
Kullmann, Frank ;
Obermeier, Florian ;
Erdmann, Johannes ;
Schmelz, Renate ;
Quasthoff, Stefan ;
Adelsberger, Helmuth ;
Bredenkamp, Rainer ;
Schmid, Roland M. ;
Lersch, Christian .
INVESTIGATIONAL NEW DRUGS, 2007, 25 (02) :173-180
[3]
Chemotherapy-induced peripheral neuropathy: pathogenesis and emerging therapies [J].
Ocean, AJ ;
Vahdat, LT .
SUPPORTIVE CARE IN CANCER, 2004, 12 (09) :619-625