醋柳黄酮自微乳化给药系统的体内外评价

被引：8

作者：

李桂玲 ^{[1
]}

范雅婷 ^{[2
]}

张燕惠 ^{[2
]}

李艳芳 ^{[3
]}

李馨儒 ^{[2
]}

刘艳 ^{[2
]}

李眉 ^{[1
]}

机构：

[1] 中国医学科学院、北京协和医学院医药生物技术研究所

[2] 北京大学药学院

[3] 北京大学第三医院

来源：

药学学报 | 2012年 / 08期

关键词：

醋柳黄酮; 自微乳化给药系统; 性质; 分散性; 小肠吸收; 生物利用度;

D O I：

暂无

中图分类号：

R943 [制剂学];

学科分类号：

100702 [药剂学];

摘要：

本文的目的在于对醋柳黄酮自微乳化给药系统进行评价,该给药系统用于提高难溶性药物醋柳黄酮的口服生物利用度。评价指标包括自微乳化时间、粒径及多分散指数、形态学特征、体外分散性、稳定性、在体小肠吸收及生物利用度。结果表明,该自微乳化给药系统在3 min内即形成微乳,平均粒径低于40 nm,多分散指数低于0.2,电镜下观察粒子形态为球形;20 min时体外累积释放百分率(以槲皮素计)接近90%,显著高于普通胶囊剂;加速试验条件下放置6个月,自微乳化给药系统的所有指标均未发生明显改变;该自微乳化给药系统的在体小肠吸收速率常数(以槲皮素计)显著高于醋柳黄酮乙醇溶液(P<0.05);以醋柳黄酮的混悬液为参比制剂,自微乳化给药系统的大鼠灌胃给药相对生物利用度(以槲皮素计)为518%。

引用

页码：1055 / 1062

页数：8

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