NLRP3 炎症体在肺损伤中的研究进展

Acute lung injury(ALI)and acute respiratory distress syndrome(ARDS)are acute respiratory failure due to acute diffuse damage to the membrane of alveolar and capillary,having the pathological features of the noncardiac pulmonary edema and inflammation.The serious stage of ALI is ARDS.Fatality rate in the clinical goes up high.Inflammation,cell apoptosis and so on play an important role in the development of ALI.A series of pathological reaction process,mediated by signal pathways becomes the focus of research.In recent years,research shows that NLRP3 Inflammasome plays a very important role in the inflammation and the cell apoptosis of ALI.It may become a new target of the treatment of lung injury.