梓醇在神经系统作用的研究进展

被引:21
作者
蔡其燕
姚忠祥
机构
[1] 第三军医大学基础医学部组织学与胚胎学教研室
关键词
梓醇; 神经系统; 神经保护; 细胞凋亡;
D O I
10.13241/j.cnki.pmb.2010.18.009
中图分类号
R285.5 [中药实验药理];
学科分类号
100806 [中药药理学];
摘要
梓醇是从地黄根部分离得到的一种环烯醚萜类化合物,具有抗炎、止痛、抗肿瘤等多种药理作用。本文拟对其物理性质、其在神经系统疾病中的作用及神经保护机制研究方面进展作一综述。对梓醇功能的进一步研究,可为神经系统疾病的治疗提供新的策略。
引用
收藏
页码:3589 / 3591+3597 +3597
页数:4
相关论文
共 9 条
[1]
Catalpol ameliorates beta amyloid–induced degeneration of cholinergic neurons by elevating brain-derived neurotrophic factors.[J].Z. Wang;Q. Liu;R. Zhang;S. Liu;Z. Xia;Y. Hu.Neuroscience.2009, 4
[2]
Catalpol protects primary cultured cortical neurons induced by Aβ 1–42 through a mitochondrial-dependent caspase pathway.[J].Jian Hua Liang;Jing Du;Lian Deng Xu;Tao Jiang;Shuang Hao;Jing Bi;Bo Jiang.Neurochemistry International.2009, 8
[3]
Catalpol protects mesencephalic neurons against MPTP induced neurotoxicity via attenuation of mitochondrial dysfunction and MAO-B activity [J].
Bi, Jing ;
Wang, Xiao-bo ;
Chen, Lei ;
Hao, Shuang ;
An, Li-jia ;
Jiang, Bo ;
Guo, Lei .
TOXICOLOGY IN VITRO, 2008, 22 (08) :1883-1889
[4]
Catalpol ameliorates cognition deficits and attenuates oxidative damage in the brain of senescent mice induced by D-galactose [J].
Zhang, Xiu Li ;
Jiang, Bo ;
Li, Zhi Bo ;
Hao, Shuang ;
An, Li Jia .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2007, 88 (01) :64-72
[5]
Neuroprotective effect of catalpol against MPP + -induced oxidative stress in mesencephalic neurons.[J].Yuan-Yuan Tian;Bo Jiang;Li-Jia An;Yong-Ming Bao.European Journal of Pharmacology.2007, 1
[6]
Catalpol increases hippocampal neuroplasticity and up-regulates PKC and BDNF in the aged rats.[J].Jing Liu;Qiao-Jie He;Wei Zou;Hong-Xia Wang;Yong-Ming Bao;Yu-xin Liu;Li-Jia An.Brain Research.2006, 1
[7]
Neuroprotective properties of catalpol in transient global cerebral ischemia in gerbils: dose–response; therapeutic time-window and long-term efficacy.[J].Dan-Qing Li;Yong-Ming Bao;Jun-Jun Zhao;Chui-Ping Liu;Ying Liu;Li-Jia An.Brain Research.2004, 2
[8]
Neuroprotection of catalpol in transient global ischemia in gerbils [J].
Li, DQ ;
Duan, YL ;
Bao, YM ;
Liu, CP ;
Liu, Y ;
An, LH .
NEUROSCIENCE RESEARCH, 2004, 50 (02) :169-177
[9]
梓醇对鱼藤酮损伤小鼠的记忆、抗氧化能力的影响及安全性评价 [J].
姜涛 ;
张爱红 ;
赵荣国 ;
姜波 .
现代生物医学进展, 2008, (06) :1039-1041+1045