GABAB受体研究现状

被引：6

作者：

李莹

刘剑峰

机构：

[1] 华中科技大学生命科学与技术学院分子生物物理教育部重点实验室

来源：

现代生物医学进展 | 2009年 / 9卷 / 16期

关键词：

GABAB受体; 激活; 失敏; 内化; 认知学习;

D O I：

10.13241/j.cnki.pmb.2009.16.011

中图分类号：

Q51 [蛋白质];

学科分类号：

071010 ; 081704 ;

摘要：

代谢型GABAB受体是C族蛋白偶联受体中的特殊的异源二聚体成员,由GABAB1亚基和GABAB2亚基组成。每个亚基在受体的激活过程中具有各自不同的功效。初步研究发现GABAB受体的活性下调方式如失敏和内化并不遵从经典的路径。近期的研究还发现GABAB受体新的生理功能,GABAB1亚基的不同亚型体在认知学习中具有重要的作用。

引用

页码：3144 / 3146

页数：3

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