偏头痛发病机制的研究进展

被引:49
作者
叶小菊
胡兴越
机构
[1] 浙江大学医学院附属邵逸夫医院神经内科
关键词
偏头痛; 发病机制; 皮质扩散抑制; 中枢致敏; 导水管周围灰质;
D O I
10.16636/j.cnki.jinn.2005.03.026
中图分类号
R747.2 [偏头痛];
学科分类号
摘要
偏头痛是一种常见的原发性头痛,其发病机制至今尚未完全阐明,近年来的研究认为由于大脑神经元兴奋性增加降低了诱发偏头痛的阈值,皮质扩散抑制活动触发先兆产生,然后三叉神经系统被激活释放血管活性肽类物质导致血管扩张和中枢致敏,再加上中枢疼痛调节系统功能异常,从而引发头痛,而导水管周围灰质进行性受损则可能是延长头痛发作时间,并使发作性偏头痛转变成慢性偏头痛的原因。
引用
收藏
页码:280 / 283
页数:4
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