二肽基肽酶-4抑制剂影响胰岛β细胞机制的研究进展

被引:4
作者
董莹
李强
机构
[1] 哈尔滨医科大学附属第二医院内分泌代谢病科
关键词
二肽基肽酶-4抑制剂; 胰岛β细胞; 内质网应激; 氧化应激; 脂毒性;
D O I
暂无
中图分类号
R587.1 [糖尿病];
学科分类号
1002 ; 100201 ;
摘要
二肽基肽酶-4(DPP-4)抑制剂减轻内质网负担和线粒体氧化应激,进而促进胰岛β细胞增殖分化;上调抗氧化应激相关的基因,如Cat、Gpxt及Sod2等,抑制硝基酪氨酸生成;下调脂质合成的基因表达,降低血载脂蛋白B、LDL-C、TG、TC和FFA水平;下调一氧化氮(NO)和TNF-α等炎症因子的浓度;刺激胰岛β细胞分泌胰淀素,但不会促进其的沉积,且对胰淀素所引起的胰岛β细胞的丧失有保护作用;从而改善了胰岛β细胞功能,增加了其质量,延缓了其衰竭。
引用
收藏
页码:953 / 955
页数:3
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